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首页> 外文期刊>The annals of pharmacotherapy >A pilot study evaluating multiple risk factor interventions by community pharmacists to prevent cardiovascular disease: The PAART CVD pilot project [Estudio piloto evaluando las intervenciones en pacientes con múltiples factores de riesgo realizadas por farmacéuticos de comunidad para prevenir enfermedad cardiovascular]
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A pilot study evaluating multiple risk factor interventions by community pharmacists to prevent cardiovascular disease: The PAART CVD pilot project [Estudio piloto evaluando las intervenciones en pacientes con múltiples factores de riesgo realizadas por farmacéuticos de comunidad para prevenir enfermedad cardiovascular]

机译：一项评估社区药师预防心血管疾病的多种风险因素干预措施的先导研究：PAART CVD试点项目[评估由社区药师预防心血管疾病的多种风险因素患者的干预措施的先导研究]

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Background: There is insufficient evidence for the efficacy of comprehensive multiple risk factor interventions by pharmacists in the primary prevention of cardiovascular disease (CVD). Given the proven benefits of pharmacist interventions for individual risk factors, it is essential that evidence for a comprehensive approach to care be generated so that pharmacists remain key members of the health care team for individuals at risk of initial onset of CVD. Objective: To establish the feasibility of an intervention delivered by community pharmacists to reduce the risk of primary onset of CVD. Methods: A single-cohort intervention study was undertaken in 2008-2009. Twelve community pharmacists from 10 pharmacies who were trained to provide lifestyle and medicine management support to reduce CVD risk recruited 70 at-risk participants aged 50-74 years who were free from diabetes or CVD. Participants received a baseline assessment to establish CVD risk and health behaviors. An assessment report provided to patients and pharmacists was used to collaboratively establish treatment goals and, over 5 sessions, implement treatment strategies. Follow-up assessment at 6 months measured changes in baseline parameters. The primary outcome was the average change to overall 5-year risk of CVD onset. Results: Sixty-seven participants were included in the analysis. The mean participant age was 60 years and 73% were female. We observed a 25% (95% CI 17 to 33) proportional risk reduction in overall CVD risk. Significant reductions also occurred in mean blood pressure (-11/-5 mm Hg) and waist circumference (-1.3 cm), with trends toward improvement for most other observed risk factors. Conclusions: Findings support previous evidence of positive cardiovascular health outcomes following pharmacist intervention in other patient groups; we recommend generating randomized controlled trial evidence for a primary prevention population.
机译：背景：目前尚无足够的证据证明药剂师采取综合的多种危险因素干预措施在心血管疾病（CVD）的一级预防中的功效。鉴于药剂师干预措施对于个体危险因素的已证明的益处，至关重要的是，要产生一种综合护理方法的证据，以使药剂师仍然是可能出现CVD初始风险的个人的医疗保健团队的关键成员。目的：确定社区药师实施干预措施以降低初次CVD风险的可行性。方法：在2008-2009年进行了单队列研究。来自10个药房的12位社区药剂师接受了提供生活方式和药物管理支持以降低CVD风险的培训，他们招募了70位50-74岁的无糖尿病或CVD风险受试者。参与者接受了基线评估，以确定CVD风险和健康行为。提供给患者和药剂师的评估报告用于共同制定治疗目标，并在5个疗程中实施治疗策略。在6个月的随访评估中测量了基线参数的变化。主要结局是发生CVD的总体5年风险的平均变化。结果：67名参与者被纳入分析。平均参与者年龄为60岁，其中73％为女性。我们观察到整体CVD风险的比例风险降低了25％（95％CI为17至33）。平均血压（-11 / -5毫米汞柱）和腰围（-1.3厘米）也显着降低，大多数其他观察到的危险因素都有改善的趋势。结论：这些发现支持了先前在其他患者组中进行药剂师干预后心血管健康结果呈阳性的证据;我们建议为一级预防人群生成随机对照试验证据。

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