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首页> 外文期刊>Chromatographia >Determination of salmeterol in equine urine and serum
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Determination of salmeterol in equine urine and serum

机译：马尿和血清中沙美特罗的测定

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Salmeterol is a beta(2)-adrenergic agonist and an Association of Racing Commissioners International (ARCI) class 3 drug. Trade names of its xinafoate salt are Arial (Dompe), Salmetedur (Menarini), and Serevent (Glaxo). Salmeterol is routinely used to increase ease of breathing in race horses during their training. Due to its bronchodilating and central nervous system stimulant properties, its administration to a horse just prior to race time has the potential to affect the horse's performance, therefore a reliable method of analysis for this compound is necessary. This paper describes a method for the identification and quantitation of salmeterol in equine urine using liquid-liquid extraction followed by liquid chromatography and tandem mass spectrometry (LC-MS-MS). Urine salmeterol concentrations peaked at about 2 h post-dose following administration of 500 ug both intravenously and intratracheally at concentrations of 14 ng mL(-1) and 4 ng mL(-1), respectively. Serum concentrations at 30 min were below the minimum level of quantitation.
机译：沙美特罗是一种β（2）-肾上腺素能激动剂，也是国际赛车委员会协会（ARCI）的3类药物。其昔萘酸盐的商品名是Arial（Dompe），Salmetedur（Menarini）和Serevent（Glaxo）。沙美特罗通常用于提高赛马训练期间的呼吸舒适度。由于其具有支气管扩张作用和中枢神经系统刺激特性，因此在赛前对马进行给药有可能影响马的表现，因此，有必要对该化合物进行可靠的分析。本文介绍了一种通过液-液萃取，液相色谱和串联质谱（LC-MS-MS）鉴定和定量马尿中沙美特罗的方法。分别以14 ng mL（-1）和4 ng mL（-1）的浓度静脉内和气管内给药500 ug后，尿中沙美特罗浓度在给药后约2小时达到峰值。 30分钟时的血清浓度低于最低定量水平。

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