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首页> 外文期刊>The Journal of pediatrics >Gamma prime fibrinogen and childhood obesity: Ready for prime time?
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Gamma prime fibrinogen and childhood obesity: Ready for prime time?

机译：伽玛血纤维蛋白原和儿童肥胖：准备好黄金时间了吗？

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The Centers for Disease Control and Prevention reports that obesity now affects 17% of American children and adolescents. Current estimates suggest 43 million children worldwide are overweight or obese, with impact across many health domains leading to both medical and psychosocial conse-quences.For the pediatric hematologist, childhood obesity is notable for its association with hypercoagulability, and the attendant risks of developing either arterial or venous thrombosis. Exactly how obesity increases the risk of clotting is not fully understood, but the hypercoagulability likely reflects a generalized prothrombotic and proinflammatory state that affects both vascular and endothelial function. Accordingly, the availability of accurate biomarkers for thrombosis among overweight and obese children could be clinically useful, particularly as risk factors for thrombotic events.In this issue of The Journal, Lovely et.al have focused on a variant form of fibrinogen, the most plentiful circulating plasma clotting factor.
机译：疾病控制与预防中心报告说，肥胖症现在影响了17％的美国儿童和青少年。目前的估计表明，全球有4300万儿童超重或肥胖，影响了许多健康领域，导致医学和社会心理方面的后果。对于儿科血液学家来说，儿童肥胖症因其与高凝性有关而引人注目，并且随之而来的风险也很大动脉或静脉血栓形成。肥胖如何增加凝血的确切风险尚不完全清楚，但高凝性可能反映了普遍的血栓形成和促炎状态，影响血管和内皮功能。因此，在超重和肥胖儿童中获得准确的血栓形成生物标志物可能在临床上是有用的，特别是作为血栓形成事件的危险因素。在《华尔街日报》这一期中，Lovely等人重点研究了纤维蛋白原的一种变体形式，其中最丰富的是循环血浆凝血因子。

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