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首页> 外文期刊>Biomarkers in medicine >Human mammaglobin: a superior marker for reverse-transcriptase PCR in detecting circulating tumor cells in breast cancer patients.
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Human mammaglobin: a superior marker for reverse-transcriptase PCR in detecting circulating tumor cells in breast cancer patients.

机译：人乳球蛋白：逆转录酶PCR的优良标记物，可检测乳腺癌患者的循环肿瘤细胞。

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摘要

Breast cancer is the most frequent cancer in women in the USA and the second most common cause of death in females who develop cancer. Recently, the detection of circulating tumor cells has emerged as a promising tool for monitoring the progression of clinically occult micrometastases in breast cancer patients. Sensitive molecular techniques, primarily based upon the reverse-transcriptase PCR, using various molecules as markers, have been developed to detect circulating tumor cells. Among those molecules, human mammaglobin mRNA has been found to be the most specific marker for the hematogenous spread of breast cancer cells. In this article, we review the current knowledge regarding the use of reverse-transcriptase PCR for detecting human mammaglobin mRNA as a biomarker for circulating tumor cells in breast cancer patients, and evaluate the clinical implications of human mammaglobin since it was first isolated in 1996.
机译：乳腺癌是美国女性中最常见的癌症，也是罹患癌症的女性中第二大最常见的死亡原因。最近，循环肿瘤细胞的检测已成为监测乳腺癌患者临床隐匿性微转移进展的有前途的工具。已经开发出主要基于逆转录酶PCR的敏感分子技术，使用各种分子作为标记，以检测循环中的肿瘤细胞。在那些分子中，人类乳球蛋白mRNA被发现是乳腺癌细胞血源性扩散的最特异标志物。在本文中，我们回顾了有关使用逆转录酶PCR检测人乳球蛋白mRNA作为乳腺癌患者循环肿瘤细胞生物标志物的最新知识，并评估了人乳球蛋白自1996年首次分离以来的临床意义。

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