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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Hypertension Secondary to Ingestion of Licorice Root Tea
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Hypertension Secondary to Ingestion of Licorice Root Tea

机译：摄入甘草根茶继发的高血压

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Objective: To report a case of hypertension secondary to ingestion of licorice root tea.Case Summary: A 46-year-old African American female with newly diagnosed stage 1 hypertension presented with a blood pressure measurement of 144/81 mm Hg and a reduced plasma potassium level of 3.2 mEq/L. The patient attempted lifestyle modifications prior to initiating an antihypertensive agent, but at a follow-up appointment, her blood pressure remained elevated. A current laboratory panel revealed a depressed morning plasma aldosterone concentration (PAC) of 5 ng/dL and low morning plasma renin activity (PRA) of 0.13 ng/mL/h. Later it was revealed that the patient regularly (1-2 cups/day) consumed "Yogi Calming" tea, a blend of herbs, including licorice root. The patient was advised to discontinue consumption of the herbal tea, and at a subsequent appointment, her blood pressure was 128/73 mm Hg and her laboratory panel had improved, including serum potassium concentration of 4.1 mEq/L, PAC of 6 ng/dL, and PRA of 0.19 ng/mL/h.Discussion: Excessive consumption of licorice has been well documented to cause pseudohyperaldosteron-ism, characterized by hypertension, hypokalemia, and suppressed plasma renin and aldosterone levels. Glycyrrhizin, the active ingredient in licorice, inhibits ll|3-hydroxysteroid dehydrogenase type 2, an oxidase responsible for the conversion and inactivation of cortisol to cortisone. Chronic ingestion of licorice-containing foods has been demonstrated to cause pseudohyperaldosteronism. These include soft candies, lozenges, and dietary supplements, but licorice-containing teas have been infrequently described. Based on the Naranjo probability score, our patient's hypertension appears to have been a probable licorice-induced reaction secondary to a licorice-containing tea.Conclusions: Herbal and dietary supplements are frequently consumed by patients without full knowledge of the contents of the products or the impact on their health. In clinical practi...
机译：目的：报告一例因摄入甘草根茶而继发的高血压病例。病例摘要：一名46岁的非洲裔美国女性，新诊断为1期高血压，血压测量为144/81 mm Hg，血浆降低钾水平为3.2 mEq / L。该患者在开始使用降压药之前尝试改变生活方式，但在随访中，血压仍然升高。当前的实验室小组显示，早晨血浆醛固酮浓度（PAC）降低至5 ng / dL，早晨血浆肾素活性（PRA）降低至0.13 ng / mL / h。后来发现，该患者定期（每天1-2杯）食用“瑜伽镇静”茶，茶是草药混合物，包括甘草根。建议患者停止饮用凉茶，在随后的预约中，她的血压为128/73 mm Hg，实验室检查结果有所改善，包括血清钾浓度为4.1 mEq / L，PAC为6 ng / dL。 ，PRA为0.19 ng / mL / h。讨论：甘草的过量食用已被证明会引起假性高醛固酮症，其特征在于高血压，低血钾症以及血浆肾素和醛固酮水平降低。甘草中的活性成分甘草甜素抑制II-3-羟基类固醇脱氢酶2型，这是一种氧化酶，负责使皮质醇转化和失活为可的松。长期摄入含有甘草的食物已被证明会引起假性醛固酮过多症。这些包括软糖，锭剂和膳食补充剂，但是鲜有描述含甘草的茶。根据Naranjo概率评分，我们的患者高血压似乎是甘草诱导的继发于含甘草茶的继发性反应。结论：患者经常食用草药和膳食补充剂，而无需完全了解产品或影响他们的健康。在临床实践中...

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