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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Osteoporosis and Vitamin D Deficiency in HIV-Positive Patients
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Osteoporosis and Vitamin D Deficiency in HIV-Positive Patients

机译：HIV阳性患者的骨质疏松症和维生素D缺乏症

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Objective: To review the epidemiology and pathophysiology of osteoporosis in patients with HIV infection and discuss vitamin D deficiency and the treatment of HIV-positive patients with osteoporosis.Data Sources: A search of PubMed (1980-June 2011) was conducted using the terms osteoporosis, HIV, vitamin D deficiency, and treatment.Study Selection and Data Extraction: Epidemiologic studies, clinical trials, and meta-analyses published in English were included. A manual review of the bibliographies of available literature was conducted and relevant articles were reviewed for inclusion.Data Synthesis: Patients with HIV infection are living longer with the use of potent antiretroviral therapy (ART) and are at increased risk for osteoporosis. Several studies have shown that HIV infection can affect bone health and increase the risk for osteoporosis. In addition, ART, and tenofovir in particular, may affect bone turnover. Studies and meta-analyses have shown an increased prevalence of osteopenia and osteoporosis in HIV-positive patients compared to noninfected controls. Recent reports also show increased prevalence of fractures and low vitamin D concentrations in HIV-positive patients. Osteoporosis treatments used in patients with HIV infection are similar to treatments for noninfected patients. HIV-positive patients should be monitored and treated to prevent the progression and complications of osteoporosis.Conclusions: HIV-positive patients are at increased risk for osteoporosis and vitamin D deficiency due to disease and treatment influences on bone health. These patients should be identified and treated to prevent the morbidity and mortality associated with osteoporosis.
机译：目的：回顾HIV感染患者的骨质疏松症的流行病学和病理生理学，探讨维生素D缺乏症和HIV阳性骨质疏松症患者的治疗。数据来源：使用骨质疏松症术语对PubMed（1980-2011年6月）进行搜索，HIV，维生素D缺乏症和治疗。研究选择和数据提取：包括流行病学研究，临床试验和以英语发表的荟萃分析。对现有文献的书目进行了人工审查，并对相关文章进行了审查。数据综合：使用有效的抗逆转录病毒疗法（ART），HI​​V感染患者的寿命更长，并且患骨质疏松症的风险增加。多项研究表明，HIV感染会影响骨骼健康并增加骨质疏松症的风险。此外，抗逆转录病毒疗法，特别是替诺福韦，可能会影响骨转换。研究和荟萃分析显示，与未感染的对照组相比，HIV阳性患者的骨质减少和骨质疏松症患病率增加。最近的报告还显示，HIV阳性患者的骨折患病率增加且维生素D浓度低。用于HIV感染患者的骨质疏松症治疗与未感染患者的治疗相似。 HIV阳性患者应接受监测和治疗，以防止骨质疏松的进展和并发症。结论：由于疾病和治疗对骨骼健康的影响，HIV阳性患者患骨质疏松症和维生素D缺乏症的风险增加。这些患者应进行识别和治疗，以预防骨质疏松症的发病率和死亡率。

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