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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Warfarin Inhibition in a Patient Taking Complementary and Alternative Medicine Products
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Warfarin Inhibition in a Patient Taking Complementary and Alternative Medicine Products

机译：服用补充和替代药物产品的患者对华法林的抑制作用

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Objective: To report a case of a decreased international normalized ratio (INR) in a patient taking warfarin in addition to multiple complementary and alternative medicine (CAM) products.Case Summary: A patient on warfarin with a target INR of 2-3 presented to the clinic with an INR of 1.1. Approximately 3 months earlier, the patient had started taking several CAM products, including omega-3 fatty acids, butcher's broom, and hawthorn berry; aloe vera juice was added approximately 6 weeks later. She was not asked to discontinue these products; instead, the warfarin dose was increased to eventually achieve a stable INR of 2.5.Discussion: An objective causality assessment suggests that this interaction was probably related to use of one of the CAMs. However, it is unclear which of these caused the decreased INR. The most likely causative agent was aloe.Conclusions: Patients do not need to discontinue CAM products while taking warfarin. However, these products need to be taken in consistent doses. Any substantial changes in intake of these substances can necessitate a change in anticoagulant therapy.
机译：目的：报告一例服用华法令的患者，除服用多种补充和替代药物（CAM）产品外的国际标准化比率（INR）下降的病例。案例摘要：一名华法林的目标INR为2-3的患者被告知INR为1.1的诊所。大约3个月前，患者开始服用几种CAM产品，包括omega-3脂肪酸，屠夫扫帚和山楂浆果。大约6周后添加芦荟汁。没有要求她停止使用这些产品;相反，增加了华法林剂量，最终使INR稳定在2.5。讨论：客观因果关系评估表明，这种相互作用可能与使用一种CAM有关。但是，目前尚不清楚其中哪些引起INR降低。结论：服用华法林的患者无需中断CAM产品。但是，这些产品需要以一致的剂量服用。这些物质摄入量的任何实质性变化都可能需要改变抗凝疗法。

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