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首页> 外文期刊>The Journal of pharmacy technology: jPT : official publication of the Association of Pharmacy Technicians >Association Between Vitamin D Levels During Pregnancy and Postpartum Depression
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Association Between Vitamin D Levels During Pregnancy and Postpartum Depression

机译：怀孕期间维生素D水平与产后抑郁之间的关联

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Objective: To evaluate evidence regarding 25-hydroxyvitamin D (25(OD)D) levels during pregnancy and its association with postpartum depression (PPD). Data Sources: Primary literature was accessed through MEDLINE, Google Scholar, and International Pharmaceutical ^w>s searches through January 2015. Data from published trials were retrieved for analysis using the following search terms: vitamin D, 25-hydroxyvitamin D, 25(OH)D, postpartum, pregnancy, and depression. Data Extraction: Inclusion criteria were human subjects, English language, vitamin D as the sole micronutrient under study, and measurement of vitamin D level during pregnancy. Studies measuring vitamin D levels after delivery were excluded. Also any antenatal or prepartum depression was excluded. Data Synthesis: Although a variety factors may contribute to the likelihood and severity of PPD, there are 3 published prospective cohort studies specifically evaluating the relationship between vitamin D and PPD. The results are conflicting: 2 of these studies found a significant correlation between patients with low vitamin D level and PPD, but the third found that high vitamin D levels are associated with a greater incidence of PPD. Conclusion: Available evidence suggests a possible correlation between vitamin D levels at midpregnancy and PPD. Women with risk factors for PPD should be educated on this potential association and ways to maintain normal vitamin D levels. Further study is needed to determine the benefit of vitamin D supplementation in preventing PPD.
机译：目的：评估有关妊娠期间25-羟基维生素D（25（OD）D）水平及其与产后抑郁症（PPD）相关的证据。数据来源：截至2015年1月，通过MEDLINE，Google Scholar和International Pharmaceuticals搜索获得了主要文献。使用以下搜索词检索了已发表试验的数据以进行分析：维生素D，25-羟基维生素D，25（OH） D，产后，妊娠和抑郁症。数据提取：纳入标准为人类受试者，英语，维生素D作为研究中的唯一微量营养素以及怀孕期间维生素D水平的测量。分娩后测量维生素D水平的研究被排除在外。此外，任何产前或产前抑郁症均不包括在内。数据综合：尽管多种因素可能会导致PPD的可能性和严重性，但有3项发表的前瞻性队列研究专门评估了维生素D与PPD之间的关系。结果是矛盾的：这些研究中有2项发现维生素D水平低的患者与PPD之间存在显着相关性，但第三项研究发现维生素D水平高的患者与PPD发生率更高相关。结论：现有证据表明，妊娠中期维生素D水平与PPD之间可能存在相关性。具有PPD危险因素的女性应接受有关这种潜在关联和维持正常维生素D水平的方法的教育。需要进一步研究以确定补充维生素D预防PPD的益处。

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