A New Vibrational Spectroscopic Tool for the Determination of Peptide Conformation:The Isotope-Edited C~(alpha)H~(alpha)Stretch Mode

Noemi G.Mirkin; Samuel Krimm

首页> 外文期刊>The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory >A New Vibrational Spectroscopic Tool for the Determination of Peptide Conformation:The Isotope-Edited C~(alpha)H~(alpha)Stretch Mode

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A New Vibrational Spectroscopic Tool for the Determination of Peptide Conformation:The Isotope-Edited C~(alpha)H~(alpha)Stretch Mode

机译：确定肽构象的新型振动光谱工具：同位素编辑的C〜（α）H〜（α）拉伸模式

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Our studies of the alanine dipeptide(ADP)vibrational frequency map(J.Phys.Chem.A 2002,706,3391)reveal that the CcH~(alpha)stretch mode,and particularly its C~(alpha)D~(alpha)isotope-edited form,is a potentially powerful tool for determining the phi,psi conformation in peptide systems.In this communication,we present ab initio C~(alpha)D~(alpha)and C~(alpha)H~(alpha)stretch frequencies of the alpha_R,beta,and polyproline II conformations of the ADP,showing that they give rise to well-separated frequencies,and discuss the kinds of experimental data needed to establish the desired structural information.

机译：我们对丙氨酸二肽（ADP）振动频率图的研究（J.Phys.Chem.A 2002,706,3391）揭示了CcH〜α拉伸模式，尤其是其C〜αD〜α模式。同位素编辑形式是确定肽系统中phi，psi构象的潜在强大工具。在此交流中，我们从头开始介绍C〜αD〜α和C〜αH〜α扩展了ADP的alpha_R，β和polyproline II构象的频率，表明它们产生了分离良好的频率，并讨论了建立所需结构信息所需的各种实验数据。

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《The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory》 |2004年第50期|共2页
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Noemi G.Mirkin; Samuel Krimm;
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正文语种 eng
中图分类物理化学（理论化学）、化学物理学;
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1. A New Vibrational Spectroscopic Tool for the Determination of Peptide Conformation:The Isotope-Edited C~(alpha)H~(alpha)Stretch Mode [J] . Noemi G.Mirkin, Samuel Krimm The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory . 2004,第50期

机译：确定肽构象的新型振动光谱工具：同位素编辑的C〜（α）H〜（α）拉伸模式
2. Conformation dependence of the (CD alpha)-D-alpha stretch mode in peptides. 1. Isolated alanine peptide structures [J] . Mirkin NG, Krimm S The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory . 2007,第24期

机译：肽中（CDα）-D-α拉伸模式的构象依赖性。 1.分离的丙氨酸肽结构
3. Spectroscopic determination of the two-dimensional vibrational potential energy surfaces for the ring-puckering and ring-flapping modes of indan in its S_0 and S_1 (#alpha#,#alpha#~*)electronic states [J] . Zane Arp, Niklas Meinander, Jaebum Choo, The Journal of Chemical Physics . 2002,第15期

机译：光谱法测定茚在S_0和S_1（#alpha＃，＃alpha＃〜*）电子状态下的环折叠和环拍模式的二维振动势能面
4. Design,synthesis,characterization and conformational studies of new potent atheroprotective amphipathic alpha-helical peptide models of apoA-I [C] . Charalampos Alexopoulos, Nicolas Coudevylle, Alexandros Tselepis International Peptide Symposium;European Peptide Symposium . 2005

机译：新有效的动脉前保护α-螺旋肽肽模型的设计，合成，表征和构象研究
5. BIOCHEMICAL STUDY OF POLY-ALPHA-L-GLUTAMIC ACID. PART I: THE EFFECT OF CONFORMATION ON THE CHEMICAL, PEPSIN OR PRONASE HYDROLYSIS OF POLY-ALPHA-L-GLUTAMIC ACID. PART II: BIOLOGICAL PROPERTIES OF POLY-ALPHA-L- GLUTAMIC ACID AND ITS DERIVATIVES. PART III: A NEW CALCIUM REQUIREMENT FOR THE HYDROLYSIS OF POLY-ALPHA-L-GLUTAMIC ACID BY THE CULTURE FILTRATESFROM BACILLUS LICHINOFORMIS. [D] . WAGLE, SUDHAKAR SHANTARAM. 1965

机译：聚α-L-谷氨酸的生物化学研究。第一部分：构象对聚-α-L-谷氨酸酸的化学，胃蛋白酶或蛋白酶水解的影响。第二部分：聚α-L-谷氨酸及其衍生物的生物学特性。第三部分：新的钙要求，用于培养滤液中的嗜酸芽孢杆菌（BACILLUS LICHINOFORMIS）水解聚-α-L-谷氨酸。
6. Conformational intermediates in the folding of a coiled-coil model peptide of the N-terminus of tropomyosin and alpha alpha-tropomyosin. [O] . N. J. Greenfield, S. E. Hitchcock-DeGregori 1993

机译：原肌球蛋白和α-α-原肌球蛋白N末端的卷曲螺旋模型肽折叠时的构象中间体。
7. Acetylcholine receptor-alpha-bungarotoxin interactions: determination of the region-to-region contacts by peptide-peptide interactions and molecular modeling of the receptor cavity. [O] . Ruan, K H, Spurlino, J, Quiocho, F A, 1990

机译：乙酰胆碱受体-α-真菌毒素相互作用：通过肽-肽相互作用和受体腔的分子模型确定区域间接触。
8. Computer-Assisted Determination of Minimum Energy Conformations. 7. A Pharmacophore Model of the Active Region of the Alpha2-Adrenoceptor. [R] . Ashman, W. P., Mickiewicz, A. P., Nelson, T. M. 1992

机译：计算机辅助确定最小能量构象。 7.α2-肾上腺素能受体活性区的药效团模型。

A New Vibrational Spectroscopic Tool for the Determination of Peptide Conformation:The Isotope-Edited C~(alpha)H~(alpha)Stretch Mode

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