...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomolecular engineering >Elicitation of predictable immune responses by using live bacterialvectors [Review]
【24h】

Elicitation of predictable immune responses by using live bacterialvectors [Review]

机译：通过使用活细菌载体引发可预测的免疫反应[评论]

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There is an increasing need for novel vaccines able to stimulate efficient and long-lasting responses, which have also low production costs. To confer protective immunity following vaccination, the adequate type of response should be elicited. Vaccines based on attenuated bacterial carriers have contained production and delivery costs, and are able to stimulate more potent immune responses than non-replicating formulations. The improved knowledge on carrier physiology and host response, the availability of different mutants and highly sophisticated expression tools, and the possibility of co-administering modulators enable to trigger predictable responses according to the specific needs. Recent studies support the use of attenuated bacteria nut only as conventional carriers, but also as a delivery system for DNA vaccines against infectious agents and tumors. In this review we discuss the most widely used bacterial carrier systems for either antigens or nucleic acid vaccines, and the strategies which have been successfully exploited to modulate the immune responses elicited.
机译：越来越需要能够刺激有效且持久的应答且生产成本也较低的新型疫苗。为了在接种疫苗后赋予保护性免疫，应引起足够的反应类型。基于减毒细菌载体的疫苗已包含生产和运输成本，并且与非复制型制剂相比，能够刺激更有效的免疫反应。对载体生理学和宿主反应的了解不断提高，各种突变体的可用性和高度复杂的表达工具，以及共同使用调节剂的可能性，可以根据特定需求触发可预测的反应。最近的研究支持减毒细菌坚果不仅用作常规载体，而且还用作抗感染因子和肿瘤的DNA疫苗的递送系统。在这篇综述中，我们讨论了用于抗原或核酸疫苗的最广泛使用的细菌载体系统，以及已成功用于调节所引发的免疫应答的策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号