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Minimization of protein adsorption on poly(vinylidene fluoride)

机译：尽量减少蛋白质在聚偏二氟乙烯上的吸附

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Surfaces covered with polyethylene glycol (PEG) have been shown to be biocompatible because PEG yields nonimmunogenicity, nonantigenicity and protein rejection. To produce a biocompatible surface coating, we have developed a method for grafting PEG onto modified poly(vinylidene fluoride) (PVDF) films. The first step was to create carboxy groups on the PVDF surface following covalente coupling of polyethylenimine (PEI) to achieve high density of amino groups. These surface amines were reacted with formyl-terminated PEG's with various molecular weight. The modified PVDF surface was characterized by means of static contact angle measurements, infrared (IR) spectroscopy and X-ray photoelectron spectroscopy (XPS). The influence of the chain length on lysozyme repellence was investigated by means of surface-MALDI-T of mass spectrometry (Surface-MALDI-Tof-MS). Lysozyme adsorption was significantly suppressed on the PEG 5000 modified PVDF surface.
机译：已经证明，用聚乙二醇（PEG）覆盖的表面具有生物相容性，因为PEG产生非免疫原性，非抗原性和蛋白质排斥。为了生产生物相容性表面涂层，我们开发了一种将PEG接枝到改性聚偏二氟乙烯（PVDF）膜上的方法。第一步是在聚乙烯亚胺（PEI）共价偶联后，在PVDF表面上产生羧基，以实现高密度的氨基。这些表面胺与具有各种分子量的甲酰基封端的PEG反应。通过静态接触角测量，红外（IR）光谱和X射线光电子能谱（XPS）表征改性的PVDF表面。通过质谱的表面MALDI-T（Surface-MALDI-Tof-MS）研究了链长对溶菌酶排斥的影响。 PEG 5000修饰的PVDF表面上的溶菌酶吸附被显着抑制。

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