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首页> 外文期刊>The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical >Dielectric Features of Neurotransmitters, γ-Aminobutyric Acid and L-Glutamate, for Molecular Recognition by Receptors
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Dielectric Features of Neurotransmitters, γ-Aminobutyric Acid and L-Glutamate, for Molecular Recognition by Receptors

机译：神经递质γ-氨基丁酸和L-谷氨酸的介电特性，用于受体的分子识别

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摘要

The neurotransmitters γ=aminiobutyric acid (GABA) and L-glutamate (Glu) have confined plate and disk geometries caused by 2 and 3 tightly hydrated water molecules in aqueous solution, respectively. They also have large dipole moments (μ): ca. 14 and 7.1 D, respectively. The direction of μ for both GABA and Glu is included in planes of the plate and disk geometries. Moreover, μ is parallel to the long molecular axis for GABA, whereas it is perpendicular to the long axis for Glu. Receptors for these neurotransmitters bear a "clamshell-like" bi-lobate structure in their ligand binding regions and maintain an open-close motion of the two lobes at a rate of ～10~8 s~(-1) in aqueous solution. These receptors detect differences in magnitude and direction of μ for GABA and Glu, allowing correct molecular recognition. As the first step of the molecular recognition process, the receptors effectively control the orientation of GABA and Glu via dipole-dipole interaction between their μ and a time-dependent dipole moment, i.e., an electric field is generated between the binding sites on the moving lobes.
机译：神经递质γ=氨基丁酸（GABA）和L-谷氨酸（Glu）具有分别由水溶液中2个和3个紧密水合的水分子引起的封闭的板和盘几何形状。它们还具有较大的偶极矩（μ）： 14和7.1D。 GABA和Glu的μ方向都包括在板和磁盘几何形状的平面中。此外，对于GABA，μ平行于长分子轴，而对于Glu，μ垂直于长轴。这些神经递质的受体在其配体结合区域具有“蛤壳状”双叶状结构，并在水溶液中以〜10〜8 s〜（-1）的速率维持两个叶的开闭运动。这些受体检测GABA和Glu的μ大小和方向的差异，从而可以正确识别分子。作为分子识别过程的第一步，受体通过它们的μ与时间相关的偶极矩之间的偶极-偶极相互作用，有效地控制GABA和Glu的方向，即在运动的结合位点之间产生电场裂片。

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