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首页> 外文期刊>The journal of physical chemistry, C. Nanomaterials and interfaces >Investigation of Magnetic Nanoparticle—Polymer Composites for Multiple-controlled Drug Delivery
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Investigation of Magnetic Nanoparticle—Polymer Composites for Multiple-controlled Drug Delivery

机译：磁性纳米粒子-聚合物复合材料用于多种控制药物的研究

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摘要

We present preliminary results obtained in the development of multiple-controlled drug delivery vehicles using magnetic nanoparticle-polymer composites. Two types of magnetic nanoparticle—polymer composites were prepared and tested for their potential as drug delivery systems with multiple controls (magnetically and thermally induced controlled delivery). These studies focused on the release of fluorescein isothiocyanate (FITC) from poly(methylmethacrylate) (PMMA), containing either magnetite or cobalt nanoparticles, by changing the sample temperature or by exposing it to an oscillating magnetic field. The magnetite—PMMA and cobalt—PMMA composites were 250 μm or less in size and were superparamagnetic. The investigations reported here demonstrated that the release of FITC from magnetite—PMMA particles can be induced thermally but not magnetically. There was no release of FITC from cobalt—PMMA composites either through thermal or magnetic induction. Characterization of the composites included transmission electron microscopy and scanning electron microscopy for size and morphology and elemental analysis for iron and cobalt content. Synchrotron radiation-based X-ray absorption near edge spectroscopy analysis was carried out to determine chemical, electronic, and geometric properties, and a superconducting quantum interference device magnetometer was utilized for measuring the magnetic properties of the composites.
机译：我们目前在使用磁性纳米粒子-聚合物复合材料的多控药物递送载体的开发中获得的初步结果。制备了两种类型的磁性纳米粒子-聚合物复合材料，并测试了其作为具有多种控制（磁性和热诱导受控递送）的药物递送系统的潜力。这些研究集中于通过改变样品温度或使其暴露于振荡磁场，从含有磁铁矿或钴纳米颗粒的聚甲基丙烯酸甲酯（PMMA）中释放异硫氰酸荧光素（FITC）。磁铁矿-PMMA和钴-PMMA复合材料的尺寸为250μm或更小，并且是超顺磁性的。此处报道的研究表明，FITC从磁铁矿-PMMA颗粒中的释放可以被热诱导而不能被磁诱导。通过热感应或磁感应，均未从钴-PMMA复合材料中释放FITC。复合材料的表征包括透射电子显微镜和扫描电子显微镜的尺寸和形貌，以及元素分析的铁和钴含量。进行了基于同步辐射的X射线吸收近边缘光谱分析，以确定化学，电子和几何性质，并使用超导量子干涉仪磁力计测量复合材料的磁性。

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