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首页> 外文期刊>The journal of physical chemistry, C. Nanomaterials and interfaces >Rare-Earth-Doped and Codoped Y2O3 Nanomaterials as Potential Bioimaging Probes
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Rare-Earth-Doped and Codoped Y2O3 Nanomaterials as Potential Bioimaging Probes

机译：稀土和共掺杂的Y2O3纳米材料作为潜在的生物成像探针。

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The synthesis and characterization of various rare-earth (RE)-doped and codoped yttrium oxide (Y2O3) nanomaterials were undertaken in the current work. RE dopants such as terbium (Tb), europium (Eu), and erbium (Er) were successfully doped, and ytterbium (Yb)—Er was codoped into Y2O3 nanomaterials. The as-synthesized nanomaterials are highly dispersed in the organic phase. X-ray diffraction peaks can be assigned to cubic Y2O3, which confirms the crystallinity of the as-prepared Y2O3 samples. Room temperature photoluminescence (PL) spectra showed characteristic emission peaks of Tb-, Eu-, and Er-doped Y2O3 samples. Up-conversion spectra of green and red emissions were also shown for Er—Yb-codoped Y2O3 samples. It was found that the intensities of the green and red emissions could be altered by varying the dopant concentration. The nanocrystals were surface-functionalized with an amine (NH2) group via a reverse microemulsion method. The amine groups render the nanocrystals water-soluble and also afford them with the possibility of further functionalization by other biomolecules. in vitro cytotoxicity studies showed that the synthesized nanocrystals have no appreciable toxicity on human hepatocellular carcinoma (Hep-G2) cells at concentrations of 0.007—0.063 mg/mL. Because of the Y2O3:RE nanomaterials' well-dispersity in water, low toxicity, and good PL, they can potentially be used as fluorophores in bioimaging.
机译：在当前工作中，进行了各种稀土（RE）掺杂和共掺杂氧化钇（Y2O3）纳米材料的合成和表征。成功掺杂了ter（Tb），euro（Eu）和（Er）等稀土元素，并将（Yb）-Er共掺杂到Y2O3纳米材料中。合成后的纳米材料高度分散在有机相中。可以将X射线衍射峰分配给立方Y2O3，这确认了所制备Y2O3样品的结晶度。室温光致发光（PL）光谱显示出Tb-，Eu-和Er掺杂的Y2O3样品的特征发射峰。还显示了掺Er-Yb的Y2O3样品的绿色和红色发射的上转换光谱。发现通过改变掺杂剂浓度可以改变绿色和红色发射的强度。经由反向微乳化方法将纳米晶体用胺（NH 2）基团表面官能化。胺基使纳米晶体具有水溶性，并且还使它们具有被其他生物分子进一步官能化的可能性。体外细胞毒性研究表明，浓度为0.007-0.063 mg / mL时，合成的纳米晶体对人肝癌细胞（Hep-G2）没有明显的毒性。由于Y2O3：RE纳米材料在水中的分散性好，毒性低和PL良好，因此它们有可能在生物成像中用作荧光团。

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