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首页> 外文期刊>The Journal of Nutritional Biochemistry >Green tea extract markedly lowers the lymphatic absorption and increases the biliary secretion of 14C-benzo[a]pyrene in rats.
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Green tea extract markedly lowers the lymphatic absorption and increases the biliary secretion of 14C-benzo[a]pyrene in rats.

机译：绿茶提取物显着降低大鼠的淋巴吸收并增加 14 C-苯并[a] py的胆汁分泌。

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摘要

Previously, we have shown that green tea extract (GTE) lowers the intestinal absorption of lipids and lipophilic compounds in rats. This study was conducted to investigate whether GTE inhibits the intestinal absorption and biliary secretion of benzo[a]pyrene (BaP), an extremely lipophilic potent carcinogen, present in foods as a contaminant. Male rats with lymph or bile duct cannula were infused at 3.0 ml/h for 8 h via a duodenal catheter with lipid emulsion containing 14C-BaP with or without GTE in PBS buffer. Lymph and bile were collected hourly for 8 h. The 14C-radioactivities in lymph, bile and intestine were determined and expressed as % dose infused. Results showed that GTE drastically lowered the lymphatic absorption of 14C-BaP (7.6+or-3.2% in GTE-infused vs. 14.4+or-2.7% dose/8 h in control rats), with a significantly higher amount of 14C-radioactivity present in the small intestinal lumen and cecum in rats infused with GTE. GTE also markedly increased the hourly rate (3.9+or-0.1% dose/h in GTE-infused vs. 3.0+or-0.1% dose/h in control rats) and the total biliary secretion of 14C-BaP (31.5+or-0.8% dose/8 h in GTE-infused vs. 24.3+or-0.4% dose/8 h in control rats). The findings provide first direct evidence that GTE has a profound inhibitory effect on the intestinal absorption of BaP and promotes the excretion of absorbed BaP via the biliary route. Further studies are warranted to investigate whether green tea could be recommended as a dietary means of ameliorating the toxicity and carcinogenic effect of BaP.
机译：以前，我们已经证明，绿茶提取物（GTE）可以降低大鼠肠道中脂质和亲脂性化合物的吸收。进行这项研究的目的是研究GTE是否抑制食物中以污染物形式存在的极亲脂性致癌物苯并[a] re（BaP）的肠道吸收和胆汁分泌。通过十二指肠导管以3.0 ml / h的速度将雄性大鼠淋巴或胆管插管注入脂质缓冲液，该脂质乳状液含有或不含有GTE的PBS缓冲液中包含 14 C-BaP。每小时收集一次淋巴和胆汁，持续8小时。测定淋巴，胆汁和肠中的 14 C放射性，并表示为注入的％剂量。结果显示，GTE显着降低了 14 C-BaP的淋巴吸收（注入GTE的大鼠的7.6+或-3.2％相对于对照组大鼠的14.4+或-2.7％的剂量/ 8 h），输注GTE的小肠腔和盲肠中的 14 C放射性含量明显更高。 GTE还显着提高了每小时速率（注入GTE的患者每小时3.9+或-0.1％剂量与对照组的3.0+或-0.1％剂量/ h）和总胆汁分泌 14 C-BaP（注入GTE的31.5 +或-0.8％剂量/ 8 h与对照组大鼠的24.3 +或-0.4％剂量/ 8 h）这些发现提供了直接的直接证据，表明GTE对BaP的肠道吸收具有深远的抑制作用，并通过胆道促进了所吸收的BaP的排泄。有必要进行进一步的研究，以调查是否可以建议将绿茶作为改善BaP毒性和致癌作用的饮食手段。

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