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首页> 外文期刊>The Journal of Nutritional Biochemistry >Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice.
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Nutritional and supranutritional levels of selenate differentially suppress prostate tumor growth in adult but not young nude mice.

机译：硒酸盐的营养和营养水平可不同程度地抑制成年小鼠而非裸鼠的前列腺肿瘤生长。

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The inhibitory effect of oral methylseleninic acid or methylselenocysteine administration on cancer cell xenograft development in nude mice is well characterized; however, less is known about the efficacy of selenate and age on selenium chemoprevention. In this study, we tested whether selenate and duration on diets would regulate prostate cancer xenograft in nude mice. Thirty-nine homozygous NU/J nude mice were fed a selenium-deficient, Torula yeast basal diet alone (Se--) or supplemented with 0.15 (Se) or 1.0 (Se+) mg selenium/kg (as Na2SeO4) for 6 months in Experiment 1 and for 4 weeks in Experiment 2, followed by a 47-day PC-3 prostate cancer cell xenograft on the designated diet. In Experiment 1, the Se-- diet enhanced the initial tumor development on days 11-17, whereas the Se+ diet suppressed tumor growth on days 35-47 in adult nude mice. Tumors grown in Se-- mice were loosely packed and showed increased necrosis and inflammation as compared to those in Se and Se+ mice. In Experiment 2, dietary selenium did not affect tumor development or histopathology throughout the time course. In both experiments, postmortem plasma selenium concentrations in Se and Se+ mice were comparable and were twofold greater than those in Se-- mice. Taken together, dietary selenate at nutritional and supranutritional levels differentially inhibit tumor development in adult, but not young, nude mice engrafted with PC-3 prostate cancer cells
机译：口服甲基硒酸或甲基硒代半胱氨酸对裸鼠癌细胞异种移植发展的抑制作用已得到很好的表征。但是，关于硒酸盐和年龄对硒化学预防的功效知之甚少。在这项研究中，我们测试了硒酸盐和饮食时间是否可以调节裸鼠体内的前列腺癌异种移植。给39只纯合的NU / J裸鼠喂食缺硒的Torula酵母基础饮食（Se--）或补充0.15（Se）或1.0（Se +）mg硒/ kg（作为Na <2> / sub> SeO 4 ）在实验1中进行了6个月，在实验2中进行了4周，然后在指定饮食下移植了47天的PC-3前列腺癌细胞。在实验1中，Se-饮食在成年裸鼠的第11-17天促进了最初的肿瘤发展，而Se +饮食在第35-47天抑制了肿瘤的生长。与Se和Se +小鼠相比，Se--小鼠中生长的肿瘤堆积松散，坏死和炎症增加。在实验2中，膳食硒在整个时间过程中均不影响肿瘤的发展或组织病理学。在这两个实验中，Se和Se +小鼠的死后血浆硒浓度是可比的，是Se-小鼠的两倍。总而言之，饮食中的硒酸盐在营养和超营养水平上均能不同程度地抑制成年但未植入PC-3前列腺癌细胞的裸鼠的肿瘤发展

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