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首页> 外文期刊>The Journal of Nutritional Biochemistry >Antihypertensive effect of passion fruit peel extract and its major bioactive components following acute supplementation in spontaneously hypertensive rats.
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Antihypertensive effect of passion fruit peel extract and its major bioactive components following acute supplementation in spontaneously hypertensive rats.

机译：自发性高血压大鼠西番莲果皮提取物及其主要生物活性成分的抗高血压作用。

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摘要

Extracts from leaves, peels or flowers of Passiflora are noted for their medicinal effects. Passiflora edulis peel extract (PFPE) has been proposed to lower blood pressure (BP); however, only indirect measurement techniques have been employed. To more accurately measure the effect of PFPE on hemodynamic parameters and determine the minimal effective dose, hemodynamic parameters were directly measured in spontaneously hypertensive rats (SHR) implanted with radiotelemeters. PFPE was given orally at 0, 2.5, 50 or 200 mg/kg body weight (BW) to determine the minimal effective dose. Once this dose was determined, the potential active components, edulilic acid (EA), anthocyanin fraction (AF) or gamma-aminobutyric acid (GABA), were tested to determine which may contribute to the reductions in BP. The 50 mg PFPE/kg BW dose was the lowest dose that significantly reduced all hemodynamic parameters from baseline when compared to control. When the potential actives were provided at equivalent doses to those found in 50 mg PFPE/kg BW, the EA and AF significantly reduced all measured hemodynamic parameters from baseline when compared to control. GABA did not significantly affect any hemodynamic parameters compared to control and significantly increased heart rate. These direct measurements indicate that PFPE can decrease hemodynamic parameters in SHR and indicate that EA and AF are active compounds that contribute to the antihypertensive effects of PFPE supplementation. While these results are encouraging, detailed mechanistic studies are needed to determine the putative value of PFPE for blood pressure control in humans
机译：西番莲叶，果皮或花朵的提取物因其药效而闻名。西番莲果皮提取物（PFPE）已被提议用于降低血压（BP）。但是，仅采用了间接测量技术。为了更准确地测量PFPE对血流动力学参数的影响并确定最小有效剂量，直接在植入了放射性遥测仪的自发性高血压大鼠（SHR）中测量了血流动力学参数。以0、2.5、50或200 mg / kg体重（BW）口服PFPE，以确定最低有效剂量。一旦确定了该剂量，就对潜在的活性成分，乙二醛酸（EA），花色苷组分（AF）或γ-氨基丁酸（GABA）进行测试，以确定哪些可能有助于降低BP。与对照组相比，50 mg PFPE / kg BW剂量是最低剂量，可从基线显着降低所有血液动力学参数。当提供与50 mg PFPE / kg BW等效剂量的潜在活性物质时，与对照相比，EA和AF显着降低了所有从基线测得的血液动力学参数。与对照相比，GABA并未显着影响任何血液动力学参数，并且明显增加了心率。这些直接的测量结果表明，PFPE可以降低SHR中的血液动力学参数，并表明EA和AF是有助于补充PFPE的降压作用的活性化合物。尽管这些结果令人鼓舞，但需要进行详细的机理研究以确定PFPE对人体血压控制的推定价值

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