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首页> 外文期刊>The Journal of Nutritional Biochemistry >Effects of excess dietary iron and fat on glucose and lipid metabolism.
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Effects of excess dietary iron and fat on glucose and lipid metabolism.

机译：日粮中铁和脂肪过多对葡萄糖和脂质代谢的影响。

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Purpose. Diets rich in fat and energy are associated with metabolic syndrome (MS). Increased body iron stores have been recognized as a feature of MS. High-fat diets (HFs), excess iron loading and MS are closely associated, but the mechanism linking them has not been clearly defined. We investigated the interaction between dietary fat and dietary Fe in the context of glucose and lipid metabolism in the body. Methods. C57BL6/J mice were divided into four groups and fed the modified AIN-93G low-fat diet (LF) and HF with adequate or excess Fe for 7 weeks. The Fe contents were increased by adding carbonyl iron (2% of diet weight) (LF+Fe and HF+Fe). Results. High iron levels increased blood glucose levels but decreased high-density lipoprotein cholesterol levels. The HF group showed increases in plasma levels of glucose and insulin and insulin resistance. HF+Fe mice showed greater changes. Representative indices of iron status, such hepatic and plasma Fe levels, were not altered further by the HF. However, both the HF and excess iron loading changed the hepatic expression of hepcidin and ferroportin. The LF+Fe, HF and HF+Fe groups showed greater hepatic fat accumulation compared with the LF group. These changes were paralleled by alterations in the levels of enzymes related to hepatic gluconeogenesis and lipid synthesis, which could be due to increases in mitochondrial dysfunction and oxidative stress. Conclusions. High-fat diets and iron overload are associated with insulin resistance, modified hepatic lipid and iron metabolism and increased mitochondrial dysfunction and oxidative stress
机译：目的。富含脂肪和能量的饮食与代谢综合症（MS）有关。人体铁存储增加已被认为是MS的功能。高脂饮食（HFs），过量铁负荷和MS密切相关，但尚未明确将它们联系起来的机制。我们研究了人体中葡萄糖和脂质代谢情况下膳食脂肪和膳食铁之间的相互作用。方法。将C57BL6 / J小鼠分为四组，并以适当或过量的Fe喂食改良的AIN-93G低脂饮食（LF）和HF，持续7周。通过添加羰基铁（日粮重量的2％）（LF + Fe和HF + Fe）可增加Fe含量。结果。高铁水平会增加血糖水平，但会降低高密度脂蛋白胆固醇水平。 HF组显示血浆葡萄糖，胰岛素水平和胰岛素抵抗增加。 HF + Fe小鼠表现出更大的变化。 HF并没有进一步改变铁状态的代表性指标，例如肝脏和血浆中的Fe水平。然而，HF和过量铁负载均改变了铁调素和铁转运蛋白的肝表达。与LF组相比，LF + Fe，HF和HF + Fe组显示出更大的肝脂肪蓄积。这些变化与与肝糖异生和脂质合成相关的酶水平的变化同时发生，这可能是由于线粒体功能障碍和氧化应激增加所致。结论。高脂饮食和铁超负荷与胰岛素抵抗，肝脂质和铁代谢改变以及线粒体功能障碍和氧化应激增加有关

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