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首页> 外文期刊>The Journal of Nutritional Biochemistry >Feeding with olive oil attenuates inflammation in dextran sulfate sodium-induced colitis in rat
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Feeding with olive oil attenuates inflammation in dextran sulfate sodium-induced colitis in rat

机译：用橄榄油喂养可减轻大鼠右旋糖酐硫酸钠诱发的结肠炎的炎症

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Chronic inflammation of long-term ulcerative colitis contributes to an increased risk of colon cancer. Few studies address whether extra-virgin olive oil (EVOO) intake suppresses inflammation, cell proliferation and signal transducers and activators of transcription (STAT) in the experimental colitis model. The aim of this study was to assess whether a 5% EVOO suppressed inflammation, increased cell proliferation and the expressions of STAT3 and STAT3 phosphorylation (pSTAT3) in dextran sulfate sodium (DSS)-induced colitis. Rats were administered DSS via drinking water (weight percentage: 4%) for 1 week with a 1-week recovery period for three cycles. Rats were divided into three groups: control group, standard diet without DSS; DSS group, standard diet+DSS; and DSS+EVOO group, EVOO diet (weight percentage: 5%)+DSS. Rats were sacrificed 5 weeks after DSS was first administered, and colonic damage was histologically and biochemically evaluated. As a result, chronic feeding of 5% EVOO attenuated inflammation. This was evaluated using a disease activity index, body weight loss and a histological score. Enhanced expressions of STAT3, pSTAT3, COX-2 and iNOS by DSS was attenuated by EVOO. In addition, EVOO attenuated increases in cell proliferation (PCNA) caused by DSS and recovered decreases in apoptosis (cleaved caspase-3). In conclusion, the study indicated that chronic feeding of 5% EVOO inhibited chronic inflammation in DSS-induced colitis in rats and also attenuated cell proliferation and recovered apoptosis in DSS colitis. (C) 2014 Elsevier Inc. All rights reserved.
机译：长期溃疡性结肠炎的慢性炎症会增加患结肠癌的风险。很少有研究解决在实验性结肠炎模型中摄取初榨橄榄油（EVOO）是否能抑制炎症，细胞增殖以及信号转导和转录激活因子（STAT）的问题。这项研究的目的是评估5％EVOO是否能抑制硫酸葡聚糖硫酸钠（DSS）引起的结肠炎的炎症反应，增加细胞增殖以及STAT3和STAT3磷酸化（pSTAT3）的表达。通过饮用水（重量百分比：4％）对大鼠给药DSS，持续1周，恢复期为1周，持续三个周期。将大鼠分为三组：对照组，无DSS的标准饮食;对照组。 DSS组，标准饮食+ DSS;和DSS + EVOO组，EVOO饮食（重量百分比：5％）+ DSS。首次给予DSS后5周将大鼠处死，并从组织学和生化方面评估结肠损伤。结果，5％EVOO的长期喂养减轻了炎症。使用疾病活动指数，体重减轻和组织学评分进行评估。 EVOO减弱了DSS增强的STAT3，pSTAT3，COX-2和iNOS的表达。此外，EVOO减缓了由DSS引起的细胞增殖（PCNA）的增加，并恢复了凋亡的减少（裂解的caspase-3）。总之，研究表明，长期饲喂5％EVOO可以抑制DSS诱导的大鼠结肠炎的慢性炎症，并减弱DSS结肠炎的细胞增殖和恢复细胞凋亡。 （C）2014 Elsevier Inc.保留所有权利。

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