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首页> 外文期刊>The Journal of Nutritional Biochemistry >Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring
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Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring

机译：产妇服用羟基酪醇可改善产前应激后代的神经发生和认知功能

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摘要

Prenatal stress is known to induce emotional and cognitive dysfunction in the offspring of both humans and experimental animals. Hydroxytyrosol (HT), a major polyphenol in olive oil with reported ability modulating oxidative stress and mitochondrial function, was performed to investigate its preventive effect on prenatal stress-induced behavioral and molecular alterations in offspring. Rats were exposed to restraint stress on days 14-20 of pregnancy. HT was given at doses of 10 and 50 mg/kg/day. The spontaneous alternation performance and Morris water maze confirmed the impaired learning capacity and memory performance induced by prenatal stress in both male and female offspring, and these effects were markedly restored in the HT supplement groups. Through tissue analysis of the hippocampi of male offspring, we found that the stress-induced downregulation of neural proteins, including BDNF, GAP43, synaptophysin, NMDAR1, NMDANR2A and NMDANR2B, was prevented by HT. Prenatal stress-induced low expression of glucocorticoid receptor was also increased by HT, although basal fetal serum corticosterone levels were not different among the four groups. Oxidative stress and mitochondrial dysfunction in prenatally stressed rats were confirmed with changes in protein oxidation, SOD activity, the expression of mitochondrial complexes and mitochondrial DNA copy number. Meanwhile, HT significantly increased transcription factors FOXO1 and FOXO3, as well as phase II enzyme-related proteins, including Nrf2 and HO-1, which may contribute to the decreased oxidative stress and increased mitochondrial function shown with HT supplementation. Taken together, these findings suggest that HT is an efficient maternal nutrient protecting neurogenesis and cognitive function in prenatally stressed offspring. (C) 2015 Elsevier Inc. All rights reserved.
机译：众所周知，产前压力会在人类和实验动物的后代中诱发情绪和认知功能障碍。羟基酪醇（HT）是橄榄油中的一种主要多酚，具有调节氧化应激和线粒体功能的能力，旨在研究其对后代应激引起的行为和分子改变的预防作用。大鼠在怀孕的第14-20天受到束缚压力。 HT的剂量为10和50 mg / kg /天。自发交替表现和莫里斯水迷宫证实了男性和女性后代的产前压力引起的学习能力和记忆能力受损，并且在HT补充剂组中这些作用得到了明显恢复。通过对雄性后代海马的组织分析，我们发现HT可以预防应激诱导的神经蛋白的下调，包括BDNF，GAP43，突触素，NMDAR1，NMDANR2A和NMDANR2B。尽管四组的基础胎儿血清皮质酮水平没有差异，但HT也增加了产前应激诱导的糖皮质激素受体低表达。通过蛋白质氧化，SOD活性，线粒体复合物的表达和线粒体DNA拷贝数的变化，证实了产前应激大鼠的氧化应激和线粒体功能障碍。同时，HT显着增加了转录因子FOXO1和FOXO3以及II期酶相关蛋白（包括Nrf2和HO-1），这可能有助于减少氧化应激并增加HT所显示的线粒体功能。综上，这些发现表明，HT是保护产前应激后代中神经发生和认知功能的有效母体营养。 （C）2015 Elsevier Inc.保留所有权利。

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