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首页> 外文期刊>The Journal of Nutritional Biochemistry >Soy protein hydrolysate ameliorates cardiovascular remodeling in rats with l-NAME-induced hypertension
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Soy protein hydrolysate ameliorates cardiovascular remodeling in rats with l-NAME-induced hypertension

机译：大豆蛋白水解物可改善l-NAME诱发的高血压大鼠的心血管重塑

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摘要

Pepsin-digested soy protein hydrolysate has been reported to be responsible for many of the physiological benefits associated with soy protein consumption. In the present study, we investigated the effects of soy protein hydrolysate with angiotensin-converting enzyme (ACE) inhibitory potential on the blood pressure and cardiovascular remodeling in rats with N s-nitro-l-arginine methyl ester hydrochloride (l-NAME)-induced hypertension. Rats were fed a diet containing l-NAME (50 mg/kg body weight) with or without soy protein hydrolysate (1%, 3% or 5%) for 6 weeks. We found that ingestion of soy protein hydrolysate retarded the development of hypertension during the 6-week experimental period without affecting the amount of food intake. Although there was no difference in plasma ACE activity or tissue nitric oxide levels, ACE activity in the heart of rats consuming soy protein hydrolysate was significantly lower than that of the control group. Moreover, cardiac malonaldehyde and tumor necrosis factor-l concentrations were also lower in the soy protein hydrolysate group. No difference in plasminogen activator inhibitor-1 level was found in plasma or cardiovascular tissue. In the histopathological analysis, we also found that soy protein hydrolysate ameliorated inflammation and left ventricle hypertrophy in the heart. These findings suggest that soy protein hydrolysate might not only improve the balance between circulating nitric oxide and renin-angiotensin system but also show beneficial effects on cardiovascular tissue through its ACE inhibitory activity.
机译：据报道，胃蛋白酶消化的大豆蛋白水解产物是与大豆蛋白消耗有关的许多生理益处的原因。在本研究中，我们研究了大豆蛋白水解产物与血管紧张素转化酶（ACE）的抑制潜力对Ns-硝基-1-精氨酸甲酯盐酸盐（l-NAME）-大鼠血压和心血管重构的影响诱发高血压。给大鼠喂食含l-NAME（50 mg / kg体重）的饮食，含或不含大豆蛋白水解物（1％，3％或5％），为期6周。我们发现，摄入大豆蛋白水解物可在6周的实验期间内延迟高血压的发展，而不会影响食物的摄入量。尽管血浆ACE活性或组织一氧化氮水平没有差异，但是消耗大豆蛋白水解产物的大鼠心脏的ACE活性显着低于对照组。此外，大豆蛋白水解产物组中心脏丙二醛和肿瘤坏死因子-1的浓度也较低。在血浆或心血管组织中未发现纤溶酶原激活物抑制剂1水平的差异。在组织病理学分析中，我们还发现大豆蛋白水解物可减轻心脏的炎症和左心室肥大。这些发现表明，大豆蛋白水解物不仅可以改善循环一氧化氮和肾素-血管紧张素系统之间的平衡，而且还可以通过其ACE抑制活性对心血管组织显示出有益的作用。

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