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首页> 外文期刊>The Journal of Nutritional Biochemistry >Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells.
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Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells.

机译：中国红曲米与单独的莫纳可林K对结肠癌细胞的抗癌作用。

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Chinese red yeast rice (RYR) is a food herb made by fermenting Monascus purpureus Went yeast with white rice. RYR contains a mixture of monacolins, one of which - monacolin K (MK) - is identical to lovastatin (LV). Epidemiological studies show that individuals taking statins have a reduced risk of colon cancer. In the present study, LV decreased cellular proliferation (P<.001) and induced apoptosis (P<.05) in HCT-116 and HT-29 human colon cancer cells. RYR inhibited both tumor cell growths (P<.001) and enhanced apoptosis (P<.05) in HCT-116 cells. Inhibition of proliferation was reversed by mevalonate (MV) in LV-treated cells, since LV is a 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCR) inhibitor. However, RYR with MV did not reverse the observed inhibition of growth. MK-free RYR did not reverse the observed LV-mediated inhibition of cancer cell growth. These observations suggest that other components in RYR, including other monacolins, pigments or the combined matrix effects of multiple constituents, may affect intracellular signaling pathways differently from purified crystallized LV in colon cancer cells. RYR was purified into two fractions: pigment-rich fraction of Chinese red yeast rice (PF-RYR) and monacolin-rich fraction of Chinese red yeast rice (MF-RYR). The effect of MF-RYR was similar to that of LV, while the effect of PF-RYR was similar to the effect of the whole RYR extract on the proliferation, apoptosis and mRNA level of HMGCR and sterol response element binding protein-2. These results suggest that the matrix effects of RYR beyond MK alone may be active in inhibiting colon cancer growth. RYR with or without MK may be a botanical approach to colon cancer chemoprevention worthy of further investigation. All rights reserved, Elsevier.
机译：中国红曲米（RYR）是一种通过将白曲霉发酵的红曲酵母发酵而制成的食用药草。 RYR包含莫纳可林的混合物，其中之一-莫纳可林K（MK）-与洛伐他汀（LV）相同。流行病学研究表明，服用他汀类药物的人患结肠癌的风险降低。在本研究中，LV降低了HCT-116和HT-29人结肠癌细胞的细胞增殖（P <.001），并诱导了细胞凋亡（P <.05）。 RYR抑制HCT-116细胞中的肿瘤细胞生长（P <.001）和增强的细胞凋亡（P <.05）。由于LV是3-羟基-3-甲基-戊二酰辅酶A还原酶（HMGCR）抑制剂，因此在LV处理的细胞中甲羟戊酸（MV）可逆转增殖抑制作用。然而，带有MV的RYR不能逆转观察到的生长抑制。不含MK的RYR不能逆转观察到的LV介导的癌细胞生长抑制作用。这些观察结果表明，RYR中的其他成分，包括其他莫纳可林脂，色素或多种成分的组合基质效应，可能对细胞内信号传导途径的影响不同于在结肠癌细胞中纯化的结晶LV。 RYR被纯化为两个部分：中国红曲米的富含色素的部分（PF-RYR）和中国红曲米的富含莫纳可林的部分（MF-RYR）。 MF-RYR的作用类似于LV，而PF-RYR的作用类似于整个RYR提取物对HMGCR和固醇反应元件结合蛋白2的增殖，凋亡和mRNA水平的作用。这些结果表明，RYR的基质效应超出MK可能在抑制结肠癌的生长中具有活性。带有或不带有MK的RYR可能是一种化学预防结肠癌的方法，值得进一步研究。保留所有权利，Elsevier。

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