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首页> 外文期刊>The journal of obstetrics and gynaecology research >Prognostic significance of thrombocytosis, platelet parameters and aggregation rates in epithelial ovarian cancer
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Prognostic significance of thrombocytosis, platelet parameters and aggregation rates in epithelial ovarian cancer

机译：上皮性卵巢癌中血小板增多，血小板参数和聚集率的预后意义

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Aim: The aim of this study is to investigate the impact of preoperative platelet counts, parameters and aggregation rates (maximal aggregation rate: MAR) on prognosis in patients with epithelial ovarian cancer (EOC). Methods: Preoperative platelet count, parameters and MAR in 182 EOC patients, 122 patients with benign ovarian tumor and 150 healthy women were retrospectively analyzed. The correlation between thrombocytosis, platelet parameters, MAR and clinicopathological factors were evaluated in EOC. Results: Forty-five (24.73%) EOC patients had preoperative thrombocytosis in this study. The mean platelet count in the EOC group was significantly higher than that of benign and healthy groups (P <0.001). The MAR in the EOC group was significantly higher than that in the healthy group (71.96% vs 57.03%, P = 0.025). The platelet parameters (mean platelet volume, platelet distribution width, thrombocytocrit and large platelet ratio) were consistently higher in the EOC group than those in the benign and healthy groups, but the differences were insignificant. A significant correlation between thrombocytosis and MAR was observed in EOC patients (r = 0.694, P <0.001). EOC patients with thrombocytosis were found to have significantly higher grade (P = 0.048), more advanced stage (P = 0.045), higher level carbohydrate antigen-125 (P = 0.007) and greater likelihood of suboptimal cytoreduction (P = 0.035). EOC patients with both thrombocytosis and high MAR were found to have shorter progression-free survival (P = 0.001)and overall survival (P = 0.004). The combination of thrombocytosis and MAR, as well as stage and optimal cytoreduction, retained significance as an independent prognostic factor for overall survival. Conclusion: Thrombocytosis, accompanied by increasing of platelet aggregation rates, is associated with more aggressive tumor biology in EOC. The combination of thrombocytosis and MAR is an independent negative prognostic factor for overall survival in EOC patients.
机译：目的：本研究的目的是调查术前血小板计数，参数和聚集率（最大聚集率：MAR）对上皮性卵巢癌（EOC）患者预后的影响。方法：回顾性分析182例EOC患者，122例卵巢良性肿瘤患者和150例健康女性的术前血小板计数，参数和MAR。在EOC中评估了血小板增多症，血小板参数，MAR和临床病理因素之间的相关性。结果：本研究中有四十五名（24.73％）EOC患者术前发生了血小板增多症。 EOC组的平均血小板计数显着高于良性和健康组（P <0.001）。 EOC组的MAR显着高于健康组（71.96％对57.03％，P = 0.025）。 EOC组的血小板参数（平均血小板体积，血小板分布宽度，血小板比容和大血小板比例）始终高于良性和健康组，但差异不显着。在EOC患者中观察到血小板增多与MAR之间存在显着相关性（r = 0.694，P <0.001）。患有血小板增多症的EOC患者被发现具有明显更高的分级（P = 0.048），更晚期（P = 0.045），更高水平的碳水化合物抗原-125（P = 0.007）和次佳的细胞减少可能性（P = 0.035）。发现患有血小板增多症和较高MAR的EOC患者的无进展生存期较短（P = 0.001），总体生存期较短（P = 0.004）。血小板增多症和MAR的组合，以及阶段性和最佳的细胞减少，仍可作为整体生存的独立预后因素。结论：血小板增多症伴随血小板聚集率增加，与EOC中更具侵略性的肿瘤生物学有关。血小板增多症和MAR的组合是EOC患者总体生存的独立阴性预后因素。

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