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首页> 外文期刊>The journal of obstetrics and gynaecology research >Effect of estradiol valerate on endometrium thickness during clomiphene citrate-stimulated ovulation
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Effect of estradiol valerate on endometrium thickness during clomiphene citrate-stimulated ovulation

机译：戊酸雌二醇对克罗米芬柠檬酸盐刺激排卵过程中子宫内膜厚度的影响

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摘要

Aim: The aim of this study was to examine the effects of estradiol valerate (EV) on the thickness of clomiphene citrate (CC)-stimulated endometrium. Material and Methods: Thirty-four normal ovulatory women were randomized double-blindly into two groups to receive CC 100 mg/day on day 2-6 of the treatment cycle, and either vitamin B (placebo) or EV 6 mg/day on day 10-14 of the cycle. The endometrial thickness, endometrial pattern, numbers of mature follicles, and maximal diameters of preovulatory follicles were evaluated by transvaginal sonographic examination. Results: Thirty women completed both treatment cycles. Two other participants dropped out during the treatment due to side-effects (headache). The average endometrial thickness of the group treated with CC + placebo became slightly thinner when compared to the thickness at the baseline (9.04 vs 9.52 mm; P = 0.24). The CC + placebo and the CC + EV resulted in similar endometrial pattern, ovulation day, numbers of mature follicles, and sizes of the leading follicles before ovulation. However, an addition of EV into the CC cycle significantly increased the average endometrial thickness (10.7 mm vs 9.04 mm; P < 0.001). Conclusions: We concluded that the addition of 6 mg/day EV following the CC treatment can prevent the endometrial thinning without perturbing folliculogenesis and ovulation.
机译：目的：本研究的目的是研究戊酸雌二醇（EV）对克罗米芬柠檬酸盐（CC）刺激的子宫内膜厚度的影响。材料和方法：将三十四名正常排卵妇女随机分为两组，在治疗周期的第2-6天每天接受CC 100毫克/天，每天接受维生素B（安慰剂）或EV 6毫克周期的10-14。通过经阴道超声检查评估子宫内膜的厚度，子宫内膜的形态，成熟卵泡的数量以及排卵前卵泡的最大直径。结果：30名妇女完成了两个治疗周期。由于副作用（头痛），其他两名参与者在治疗期间退出了研究。与基线时的厚度相比，用CC +安慰剂治疗的组的平均子宫内膜厚度变得稍薄（9.04对9.52 mm; P = 0.24）。 CC +安慰剂和CC + EV导致相似的子宫内膜形态，排卵日，成熟卵泡数和排卵前先卵泡的大小。但是，在CC周期中增加EV会显着增加平均子宫内膜厚度（10.7 mm对9.04 mm; P <0.001）。结论：我们得出的结论是，CC治疗后添加6 mg / day EV可以防止子宫内膜变薄而不会干扰卵泡生成和排卵。

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