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首页> 外文期刊>The Journal of Nutritional Biochemistry >Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk
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Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk

机译：新生儿，婴儿，儿童，母乳喂养的妇女，母乳喂养的婴儿和人母乳中的胆碱状态

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This study assessed the choline status in newborns, infants, children, breast-feeding women, breast milk, infant formula, breast-fed and formula-fed infants. The serum free choline level was 35.1 +- 1.1 umol/L at birth and decreased to 24.2 +- 1.6, 18.1+0.8, 16.3 +- 0.9, 14.3 +- 0.8, 12.9 +- 0.6 or 10.9 +- 0.6 umol/L at 22-28, 151-180, 331-365, 571-730, 731-1095 or 4016-4380 days after birth, respectively. The serum phospholipid-bound choline level was 1997 +- 75 umol/L at birth and increased gradually to 2315 +- 190 or 2572 +- 100 umol/L at 571-730 or 4016-4380 days after birth, respectively. In breast-feeding women, serum free and phospholipid-bound choline levels were doubled at 12-28 days after birth, they decreased toward the control valueswith time. Free choline, phosphocholine and glycerophosphocholine were major choline compounds in breast milk. Their concentrations in mature milk were much greater than in colostrum and serum. Choline contents of breast milk varied greatly between mothers, and milk free choline levels were correlated with serum free choline (r=.541; P<.001), phospholipid-bound choline (r=.527; P<.001) and glycerophosphocholine (r=.299; P<.01) concentrations and lactating days (r=.520; P<.001). In breast-fed infants, serum free choline concentrations were correlated with free choline (r=.47; P<.001), phosphocholine (r=.345; P<.002), glycerophosphocholine (r=.311; P<.01) and total choline (r=.306; P<.01) contents of breast milk. Serum free choline concentration in formula-fed infants was lower than breast-fed infants. These data show that (a) circulating choline status is elevated during infancy and lactation, (b) choline contents of breast milk vary between mothers and milk free choline contents are influenced by maternal circulating choline status, and (c) the choline contents of breast milk can influence infants' circulating choline status.
机译：这项研究评估了新生儿，婴儿，儿童，母乳喂养的妇女，母乳，婴儿配方奶粉，母乳喂养和配方奶喂养的婴儿的胆碱状态。出生时血清游离胆碱水平为35.1±1.1 umol / L，在出生时降至24.2±1.6、18.1 + 0.8、16.3±0.9、14.3±0.8、12.9±0.6或10.9±0.6 umol / L分别在出生后22-28、151-180、331-365、571-730、731-1095或4016-4380天。出生时血清磷脂结合的胆碱水平为1997±75 umol / L，出生后571-730或4016-4380天逐渐升高至2315±190或2572±100 umol / L。在母乳喂养的妇女中，无血清和磷脂结合的胆碱水平在出生后12-28天翻了一番，随着时间的推移，它们朝着对照值下降。游离胆碱，磷酸胆碱和甘油磷酸胆碱是母乳中的主要胆碱化合物。它们在成熟牛奶中的浓度远高于初乳和血清中的浓度。母亲之间母乳中的胆碱含量差异很大，无奶胆碱水平与无血清胆碱（r = .541; P <.001），磷脂结合胆碱（r = .527; P <.001）和甘油磷酸胆碱相关。 （r ＝ .299; P ＜.01）浓度和哺乳天数（r ＝ .520; P ＜.001）。在母乳喂养的婴儿中，血清游离胆碱浓度与游离胆碱（r = .47; P <.001），磷酸胆碱（r = .345; P <.002），甘油磷酸胆碱（r = .311; P <）相关。 01）和母乳中的总胆碱含量（r = .306; P <.01）。配方奶喂养婴儿的血清游离胆碱浓度低于母乳喂养婴儿。这些数据表明：（a）在婴儿期和哺乳期循环胆碱状态会升高;（b）母亲之间母乳中胆碱含量会发生变化;无乳胆碱含量会受到母亲循环胆碱状态的影响;（c）乳房胆碱含量会受到影响牛奶会影响婴儿的循环胆碱状态。

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