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首页> 外文期刊>The Journal of Nutritional Biochemistry >Vitamin D-3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats
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Vitamin D-3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats

机译：维生素D-3恢复链脲佐菌素诱发的糖尿病大鼠胰腺皮质胆碱能和胰岛素受体表达的改变以及胰岛M3受体表达的改变

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Nutritional therapy is a challenging but necessary dimension in the management of diabetes and neurodegenerative changes associated with it. The study evaluates the effect of vitamin D-3 in preventing the altered function of cholinergic, insulin receptors and GLUT3 in the cerebral cortex of diabetic rats. Muscarinic M3 acetylcholine receptors in pancreas control insulin secretion. Vitamin D-3 treatment in M3 receptor regulation in the pancreatic islets was also studied. Radioreceptor binding assays and gene expression was done in the cerebral cortex of male Wistar rats. Immunocytochemistry of muscarinic M3 receptor was studied in the pancreatic islets using specific antibodies. Y-maze was used to evaluate the exploratory and spatial memory. Diabetes induced a decrease in muscarinic M1, insulin and vitamin D receptor expression and an increase in muscarinic M3, alpha 7 nicotinic acetylcholine receptor, acetylcholine esterase and GLUT3 expression. Vitamin D-3 and insulin treatment reversed diabetes-induced alterations to near control. Diabetic rats showed a decreased Y-maze performance while vitamin D-3 supplementation improved the behavioural deficit. In conclusion, vitamin D-3 shows a potential therapeutic effect in normalizing diabetes-induced alterations in cholinergic, insulin and vitamin D receptor and maintains a normal glucose transport and utilisation in the cortex. In addition vitamin D-3 modulated muscarinic M3 receptors activity in pancreas and plays a pivotal role in controlling insulin secretion. Hence our findings proved, vitamin D-3 supplementation as a potential nutritional therapy in ameliorating diabetes mediated cortical dysfunctions and suggest an interaction between vitamin D-3 and muscarinic M3 receptors in regulating insulin secretion from pancreas
机译：在糖尿病和与之相关的神经退行性改变的管理中，营养疗法是一个具有挑战性但必不可少的方面。这项研究评估了维生素D-3预防糖尿病大鼠大脑皮层中胆碱能，胰岛素受体和GLUT3功能改变的作用。胰腺中的毒蕈碱型M3乙酰胆碱受体可控制胰岛素分泌。还研究了维生素D-3在胰腺胰岛M3受体调节中的作用。在雄性Wistar大鼠的大脑皮层中进行了放射性受体结合测定和基因表达。使用特异性抗体在胰岛中研究了毒蕈碱M3受体的免疫细胞化学。 Y迷宫用于评估探索性和空间记忆。糖尿病导致毒蕈碱M1，胰岛素和维生素D受体表达减少，毒蕈碱M3，α7烟碱乙酰胆碱受体，乙酰胆碱酯酶和GLUT3表达增加。维生素D-3和胰岛素治疗可将糖尿病引起的改变逆转为接近控制。糖尿病大鼠表现出降低的Y-迷宫性能，而补充维生素D-3改善了行为缺陷。总之，维生素D-3在使糖尿病引起的胆碱能，胰岛素和维生素D受体改变正常化方面显示出潜在的治疗效果，并在皮质中维持正常的葡萄糖转运和利用。另外，维生素D-3调节胰腺中的毒蕈碱M3受体活性，并在控制胰岛素分泌中起关键作用。因此，我们的研究结果证明，补充维生素D-3可作为改善糖尿病介导的皮质功能障碍的潜在营养疗法，并表明维生素D-3和毒蕈碱M3受体之间的相互作用可调节胰腺的胰岛素分泌

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