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首页> 外文期刊>The Journal of Nutritional Biochemistry >Down-regulation of vascular HMGB1 and RAGE expression by n-3 polyunsaturated fatty acids is accompanied by amelioration of chronic vasculopathy of small bowel allografts
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Down-regulation of vascular HMGB1 and RAGE expression by n-3 polyunsaturated fatty acids is accompanied by amelioration of chronic vasculopathy of small bowel allografts

机译：n-3多不饱和脂肪酸对血管HMGB1和RAGE表达的下调伴随着小肠同种异体移植的慢性血管病的缓解

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摘要

Chronic allograft rejection, which is manifested as chronic allograft vasculopathy (CAV), continues to refrain the long-term success of small bowel transplantation (SBTx). The pathway mediated by the receptor for advanced glycation end products (RAGE) and its ligand, high mobility group box-1 (HMGB1), may contribute to the pathogenesis of CAV, given that they were involved in the process of allograft rejection. n-3 polyunsaturated fatty acids (PUFAs), which have been discovered to attenuate CAV, may have potential impacts on this pathway. The present study investigated whether n-3 PUFAs attenuated CAV via the regulation of the HMGB1-RAGE pathway in a chronic rejection model of rat SBTx. We revealed that the expression of HMGB1 and RAGE was increased in CAV-bearing vessels as well as endothelial cells isolated from these vessels. Oral administration of fish oil with high levels of n-3 PUFAs following SBTx significantly reduced the HMGB1 and RAGE expression, which coincided with the amelioration of CAV. In contrast, feeding of corn oil that contained low levels of n-3 PUFAs had no favorable effects on CAV development and failed to decrease the HMGB1 and RAGE expression. These results indicate that protective effects of n-3 PUFAs on allograft vessels exist via down-regulation of the HMGB1-RAGE pathway.
机译：慢性同种异体移植排斥反应表现为慢性同种异体移植血管病变（CAV），继续阻碍小肠移植（SBTx）的长期成功。鉴于晚期糖基化终产物（RAGE）的受体及其配体高迁移率基团box-1（HMGB1）介导的通路可能参与了CAV的发病机制，因为它们参与了同种异体移植排斥的过程。已发现可减弱CAV的n-3多不饱和脂肪酸（PUFA）可能对该途径有潜在影响。本研究调查了在大鼠SBTx慢性排斥模型中n-3 PUFA是否通过HMGB1-RAGE途径的调节来减弱CAV。我们发现HMGB1和RAGE的表达在带有CAV的血管以及从这些血管分离的内皮细胞中增加了。 SBTx后口服高含量n-3 PUFA的鱼油可显着降低HMGB1和RAGE表达，这与CAV的改善同时发生。相反，饲喂低水平n-3 PUFA的玉米油对CAV的发育没有有利影响，并且不能降低HMGB1和RAGE表达。这些结果表明，n-3 PUFA对同种异体移植血管的保护作用是通过下调HMGB1-RAGE途径而实现的。

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