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首页> 外文期刊>The Journal of Nutritional Biochemistry >The acai flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF- alpha and IL-6 production through inhibiting NF- kappaB activation and MAPK pathway.
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The acai flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF- alpha and IL-6 production through inhibiting NF- kappaB activation and MAPK pathway.

机译：阿拉伯胶类黄酮维他汀是一种有效的抗炎药：通过抑制NF-κB激活和MAPK途径来阻断LPS介导的TNF-α和IL-6的产生。

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摘要

Recent studies have shown that some flavonoids are modulators of proinflammatory cytokine production. In this study, velutin, a unique flavone isolated from the pulp of acai fruit (Euterpe oleracea Mart.), was examined for its effects in reducing lipopolysaccharide-induced proinflammatory cytokine tumor necrosis factor (TNF)- alpha and interleukin (IL)-6 production in RAW 264.7 peripheral macrophages and mice peritoneal macrophages. Three other structurally similar and well-studied flavones, luteolin, apigenin and chrysoeriol, were included as controls and for comparative purposes. Velutin exhibited the greatest potency among all flavones in reducing TNF- alpha and IL-6 production. Velutin also showed the strongest inhibitory effect in nuclear factor (NF)- kappaB activation (as assessed by secreted alkaline phosphatase reporter assay) and exhibited the greatest effects in blocking the degradation of inhibitor of NF- kappaB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation; all of these are important signaling pathways involved in production of TNF- alpha and IL-6. The present study led to the discovery of a strong anti-inflammatory flavone, velutin. This compound effectively inhibited the expression of proinflammatory cytokines TNF- alpha and IL-6 in low micromole levels by inhibiting NF- kappaB activation and p38 and JNK phosphorylation
机译：最近的研究表明，某些类黄酮是促炎细胞因子产生的调节剂。在这项研究中，velutin是从巴西莓果肉中分离出的独特黄酮（Euterpe oleracea Mart。），其在减少脂多糖诱导的促炎性细胞因子肿瘤坏死因子（TNF）-α和白介素（IL）-6的作用方面得到了研究在RAW 264.7外周巨噬细胞和小鼠腹膜巨噬细胞中产生。包括三个其他在结构上相似且经过充分研究的黄酮，木犀草素，芹菜素和金鸡油，作为对照并用于比较。 Velutin在所有黄酮中表现出最大的功效，可降低TNF-α和IL-6的产生。 Velutin在核因子（NF）-κB活化中也表现出最强的抑制作用（通过分泌性碱性磷酸酶报告基因分析评估），并且在阻断NF-κB抑制剂的降解以及抑制丝裂原活化蛋白方面表现出最大的作用。激酶p38和JNK磷酸化;所有这些都是涉及TNF-α和IL-6产生的重要信号通路。本研究导致发现了一种强大的消炎性黄酮velutin。该化合物通过抑制NF-κB的活化以及p38和JNK的磷酸化，以低微摩尔浓度有效抑制促炎细胞因子TNF-α和IL-6的表达。

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