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首页> 外文期刊>The Journal of Nutritional Biochemistry >Bifidobacterium adolescentis protects from the development of nonalcoholic steatohepatitis in a mouse model
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Bifidobacterium adolescentis protects from the development of nonalcoholic steatohepatitis in a mouse model

机译：青春双歧杆菌可保护小鼠模型免于非酒精性脂肪性肝炎的发展

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摘要

To investigate the hypothesis that an oral supplementation of Bifidobacterium adolescentis protects against a diet-induced nonalcoholic steatohepatitis in a mouse model, C57BL/6 mice were fed either a Western-style or a control diet +/- tap water fortified with B. adolescentis (5x10(7) cfu/ml) ad libitum for 12 weeks. Mice fed a Western-style diet gained significantly more weight than mice fed a control diet and developed a mild steatohepatitis. Western-style diet fed groups concomitantly treated with B. adolescentis had significantly decreased liver damage, whereas portal endotoxin levels and toll-like receptor-4 protein levels as well as myeloid differentiation factor 88 mRNA were increased in livers of both Western-style diet fed groups. The protective effects of the B. adolescentis were associated with a significant attenuation of the formation of reactive oxygen species, activation of nuclear factor kappa B (NF kappa B) and induction of markers of inflammation in the liver. Taken together, our data suggest that an oral supplementation of the B. adolescentis attenuates diet-induced steatohepatitis, and this effect is associated with prevention from lipid peroxidation, NF kappa B activation and finally inflammation in the liver. (C) 2014 Elsevier Inc. All rights reserved.
机译：为了研究假说，在小鼠模型中口服青春双歧杆菌可以预防饮食引起的非酒精性脂肪性肝炎，对C57BL / 6小鼠喂以西式或对照饮食+/-强化了青春双歧杆菌的自来水（随意使用5x10（7）cfu / ml），持续12周。饲喂西式饮食的小鼠体重增加明显超过饲喂对照饮食的小鼠，并发展为轻度脂肪性肝炎。伴有青春双歧杆菌的西式饮食喂养组的肝脏损害显着降低，而两种西式饮食喂养的肝脏中，门静脉内毒素水平和toll样受体4蛋白水平以及髓系分化因子88 mRNA均升高组。青少年芽孢杆菌的保护作用与活性氧形成的显着减弱，核因子κB（NFκB）的活化和肝中炎症标志物的诱导有关。综上所述，我们的数据表明，口服青少年青春芽孢杆菌可减轻饮食引起的脂肪性肝炎，并且这种作用与预防脂质过氧化，NFκB活化以及最终肝脏炎症有关。 （C）2014 Elsevier Inc.保留所有权利。

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