• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Nutritional Biochemistry >Oxidized frying oil and its polar fraction fed to pregnant mice are teratogenic and alter mRNA expressions of vitamin A metabolism genes in the liver of dams and their fetuses
【24h】

Oxidized frying oil and its polar fraction fed to pregnant mice are teratogenic and alter mRNA expressions of vitamin A metabolism genes in the liver of dams and their fetuses

机译：氧化的煎炸油及其极性部分喂给怀孕的小鼠会致畸，并会改变大坝及其胎儿肝脏中维生素A代谢基因的mRNA表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We previously observed a higher incidence of congenital malformations in the fetuses of dams fed an oxidized frying oil (OFO)-containing diet during pregnancy. In this study, we hypothesized that, during pregnancy, maternal ingestion of OFO, specifically the oxidized components (i.e. the polar fraction), modulates peroxisome proliferator-activated receptor (PPAR alpha) or aryl hydrocarbon receptor (AhR) transactivity, altering the metabolism of retinoic acid (RA), a well-characterized morphogen, resulting in teratogenesis. Pregnant C57BL/6J mice were divided into four groups which, from d1 (conception) to d18, were fed a diet containing 10 g/100 g of fresh soybean oil (SO), OF or the non-polar (NP) or polar (PO) fraction of OFO. Reporter assays testing the transactivity of PPAR alpha and AhR showed that free fatty acids from OFO, specifically the PO fraction, up-regulated PPAR alpha transactivity and down-regulated AhR transactivity. In vivo study showed that the PO fraction group had a significantly higher number of dead fetuses and resorptions per litter than the SO and NP fraction groups. The incidence of abnormalities in terms of gross morphology and skeletal ossification of the fetus was greatest in the PO fraction group, followed by the OF group, both values being significantly higher than in the other two groups. Hepatic expression of genes encoding enzymes associated with RA synthesis and catabolism in dams and fetuses was differentially affected by PO fraction assault. We conclude that OFO-mediated teratogenesis is associated with disturbed RA metabolism in the dams and fetuses caused, at least in part, by modulation of PPAR alpha and AhR transactivity by the oxidized components in OFO. (C) 2014 Elsevier Inc. All rights reserved.
机译：我们以前曾观察到在怀孕期间以含氧化油炸油（OFO）的饮食喂养的大坝胎儿的先天畸形发生率更高。在这项研究中，我们假设孕妇在怀孕期间摄入OFO，特别是氧化成分（即极性部分）会调节过氧化物酶体增殖物激活受体（PPARα）或芳烃受体（AhR）的交易性，从而改变视黄酸（RA）是一种特征丰富的形态发生剂，可导致致畸。将怀孕的C57BL / 6J小鼠分为4组，从d1（受孕）到d18，分别喂食10 g / 100 g新鲜大豆油（SO），OF或非极性（NP）或极性（ PO）OFO的分数。记者分析测试PPARα和AhR的活性，发现来自OFO的游离脂肪酸，特别是PO组分，上调了PPARα的活性，而下调了AhR的活性。体内研究表明，与SO和NP组分组相比，PO组分组每胎的死胎和吸收量要高得多。就胎儿的总体形态和骨骼骨化而言，异常的发生率在PO分数组中最大，其次是OF组，这两个值均明显高于其他两组。 PO组分攻击差异性地影响大坝和胎儿中与RA合成和分解代谢相关的酶的编码基因的肝表达。我们得出的结论是，OFO介导的致畸作用与大坝和胎儿中RA代谢紊乱有关，至少部分是由OFO中的氧化成分对PPARα和AhR传递性的调节引起的。 （C）2014 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号