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首页> 外文期刊>The Journal of Nutritional Biochemistry >Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults.
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Effects of isoflavone supplements vs. soy foods on blood concentrations of genistein and daidzein in adults.

机译：异黄酮补充剂与大豆食品对成年人中染料木黄酮和大豆苷元的血药浓度的影响。

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The objective of this investigation was to examine the pharmacokinetics of isoflavone concentrations over a 24-h period among healthy adults consuming either soy foods or soy isoflavone tablets at different doses. This randomized, cross-over trial was conducted with 12 generally healthy adults. The three phases of the intervention included isoflavone tablets at (1) 144 mg/day or (2) 288 mg/day and (3) soy foods designed to provide a calculated 96 mg isoflavones/day (doses in aglycone equivalents). Doses were spread out over three meals per day. After 6 days on each study phase, plasma isoflavone concentrations were determined on the seventh day at 0, 4, 8, 10, 12 and 24 h. Average levels of total isoflavone concentrations at 8, 10 and 12 h were >4 mumol/L for the soy food phase and for the higher dose tablet phase. Genistein concentrations were higher overall in the soy food vs. both the lower and the higher dose supplement phases of the study (P<.05). When comparing plasma concentrations for the two doses of tablets, saturation appeared more evident for genistein than for daidzein at the higher dose level. In conclusion, we observed important differences in the pharmacokinetics of genistein and daidzein contrasting the sources and doses of isoflavones when administered three times daily, including a possible advantage for increasing serum concentrations of isoflavones from consuming soy foods relative to isoflavone supplements. All rights reserved, Elsevier.
机译：这项研究的目的是检查健康成年人中以不同剂量摄入大豆食品或大豆异黄酮片的24小时内异黄酮浓度的药代动力学。这项随机，交叉试验是针对12位总体健康的成年人进行的。干预的三个阶段包括异黄酮片，分别为（1）144 mg /天或（2）288 mg /天，以及（3）旨在提供96 mg异黄酮/天的大豆食品（糖苷配基的剂量）。每天分发三餐以上的剂量。每个研究阶段6天后，在第7天的0、4、8、10、12和24小时测定血浆异黄酮浓度。对于大豆食品相和较高剂量片剂相，在8、10和12 h时，总异黄酮的平均浓度> 4 mumol / L。大豆食品中的染料木黄酮浓度总体上高于研究的较低和较高剂量补充阶段（P <.05）。当比较两种剂量片剂的血浆浓度时，在较高剂量水平下，染料木黄酮的饱和度似乎比黄豆苷元更明显。总之，我们观察到染料木黄酮和大豆苷元在药代动力学方面的重要差异，对比了每天给药3次时异黄酮的来源和剂量，这包括相对于补充异黄酮而言，食用大豆食品可提高异黄酮的血清浓度。保留所有权利，Elsevier。

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