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首页> 外文期刊>The journal of obstetrics and gynaecology research >Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages
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Comparison of reproductive outcome, including the pattern of loss, between couples with chromosomal abnormalities and those with unexplained repeated miscarriages

机译：染色体异常的夫妇与无法解释的反复流产的夫妇之间生殖结果的比较，包括损失的方式

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Aim: Chromosomal abnormalities are an important cause of repeated miscarriage. Several studies have discussed the association between chromosomal abnormalities and repeated miscarriage. This study attempts to describe the pattern of miscarriage in this group of women and the eventual pregnancy outcome of couples with chromosomal abnormalities compared with couples with unexplained repeated pregnancy loss. Material and Methods: This was a retrospective study involving 795 couples with repeated miscarriages. Results: Out of 795 couples, 28 (3.52%) were found to have a chromosomal abnormality (carrier group). Over half (65.5%) of the chromosomal abnormalities were balanced reciprocal translocations. After referral, this carrier group had a total of 159 pregnancies, leading to 36 live births (22.6%) among 18 couples. The after referral miscarriage rate in the chromosomal anomaly group (55.6%) was significantly (P < 0.01) higher than that in the unexplained recurrent miscarriage group (28.1%). In couples with chromosomal anomaly, the miscarriages were more likely to occur between 6 and 12 weeks' gestation. Conclusions: The encouraging cumulative live birth rate of 64.3% for couples with chromosomal anomaly and repeated miscarriage suggests that further attempts at natural conception are a viable option.
机译：目的：染色体异常是反复流产的重要原因。几项研究讨论了染色体异常与反复流产之间的关系。这项研究试图描述这一组妇女的流产方式，以及染色体异常的夫妇与无法解释的反复妊娠的夫妇相比，最终的妊娠结局。材料和方法：这是一项回顾性研究，涉及795对反复流产的夫妇。结果：在795对夫妇中，发现28对（3.52％）染色体异常（携带者组）。超过一半（65.5％）的染色体异常是平衡的相互易位。转诊后，该携带者组总共有159例怀孕，导致18对夫妇中有36例活产（22.6％）。染色体异常组的转诊后流产率（55.6％）明显高于未解释的复发性流产组（28.1％）（P <0.01）。在患有染色体异常的夫妇中，流产更有可能在妊娠6至12周之间发生。结论：对于染色体异常和反复流产的夫妇，令人鼓舞的累计活产率为64.3％，这表明进一步尝试自然受孕是可行的选择。

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