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首页> 外文期刊>The Journal of Nutritional Biochemistry >Enterohepatic circulation of organochlorine compounds: a site for nutritional intervention
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Enterohepatic circulation of organochlorine compounds: a site for nutritional intervention

机译：有机氯化合物的肠肝循环：营养干预的场所

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摘要

Organochlorine compounds enter the body primarily as components of the diet. Their removal from the body is via excretion into the feces. There is evidence that many people are in a positive balance, with the rate of intake of organochlorines exceeding that of their excretion. A desirable nutritional approach to this problem would both reduce dietary intake and increase fecal excretion. Nonabsorbable dietary lipids reduce the absorption of dietary organochlorines and also increase the rate of their fecal excretion. Organochlorine compounds that are stored in the body enter the intestine both in bile and through a poorly understood nonbiliary mechanism. Part of the amount that enters the intestine is excreted, and part is reabsorbed in an enterohepatic circulation. There is evidence that an increase in excretion can be achieved by interference with the enterohepatic circulation of organochlorine compounds and their metabolites. Data from animals and humans show that the presence of nonabsorbed lipid in the intestine can increase the rate of excretion in a clinically significant manner.
机译：有机氯化合物主要作为饮食的成分进入人体。它们通过排泄到粪便中而从体内清除。有证据表明，许多人处于正平衡状态，有机氯的摄入量超过其排泄量。解决该问题的理想营养方法将减少饮食摄入并增加粪便排泄。不可吸收的饮食脂质减少了饮食中有机氯的吸收，也增加了粪便排泄的速度。体内储存的有机氯化合物会通过胆汁和人们鲜为人知的非胆汁机制进入肠道。进入肠道的部分量被排泄，一部分在肝肠循环中被重新吸收。有证据表明，可以通过干扰有机氯化合物及其代谢产物的肠肝循环来增加排泄。来自动物和人类的数据表明，肠道中未吸收脂质的存在可以临床上显着的方式增加排泄率。

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