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首页> 外文期刊>The Journal of Nutritional Biochemistry >Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
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Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention

机译：膳食类黄酮对癌症化学预防相关凋亡途径的影响

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摘要

Epidemiological studies have described the beneficial effects of dietary polyphenols (flavonoids) on the reduction of the risk of chronic diseases, including cancer. Moreover, it has been shown that flavonoids, such as quercetin in apples, epigallocatechin-3-gallate in green tea and genistein in soya, induce apoptosis. This programmed cell death plays a critical role in physiological functions, but there is underlying dysregulation of apoptosis in numerous pathological situations such as Parkinson's disease, Alzheimer's disease and cancer. At the molecular level, flavonoids have been reported to modulate a number of key elements in cellular signal transduction pathways linked to the apoptotic process (caspases and bcl-2 genes), but that regulation and induction of apoptosis are unclear. The aim of this review is to provide insights into the molecular basis of the potential chemopreventive activities of representative flavonoids, with emphasis on their ability to control intracellular signaling cascades responsible for regulating apoptosis, a relevant target in cancer-preventive approach.
机译：流行病学研究描述了饮食中多酚（类黄酮）对降低包括癌症在内的慢性疾病风险的有益作用。而且，已经表明类黄酮，例如苹果中的槲皮素，绿茶中的表没食子儿茶素-3-没食子酸酯和大豆中的染料木黄酮诱导细胞凋亡。这种程序性的细胞死亡在生理功能中起着至关重要的作用，但是在许多病理情况下，例如帕金森氏病，阿尔茨海默氏病和癌症中，潜在的细胞凋亡失调。在分子水平上，据报道黄酮类化合物调节与凋亡过程相关的细胞信号转导途径中的许多关键元素（胱天蛋白酶和bcl-2基因），但尚不清楚细胞凋亡的调控和诱导作用。这篇综述的目的是提供对代表性黄酮类化合物潜在化学预防活性的分子基础的见解，重点在于它们控制负责调节细胞凋亡的细胞内信号级联反应的能力，而细胞内信号级联反应是癌症预防方法中的一个相关目标。

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