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首页> 外文期刊>The Journal of Nutritional Biochemistry >Factors associated with longitudinal plasma selenium decline in the elderly: the EVA study
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Factors associated with longitudinal plasma selenium decline in the elderly: the EVA study

机译：老年人血浆纵向硒水平下降的相关因素：EVA研究

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Selenium status decreases in elderly populations. Cardiovascular diseases are the primary cause of death in the French elderly, and selenium may protect against cardiovascular diseases. The present work aims to evaluate the relationships between cardiovascular-related risk factors and plasma selenium variability in an elderly population during a 9-year period. Seven hundred fifty-one subjects from the EVA ("Etude du Vieillissement Arteriel") study, aged 59 to 71 at baseline, were followed for 9 years. Clinical examinations and lifestyle questionnaires were repeated every 2 years. Plasma selenium determinations were performed at baseline and at the end of the study. The association between the 9-year plasma selenium variability and studied risk factors at baseline or occurring during the follow-up was evaluated by using multivariate linear regression models. After controlling all potential associated factors, age of subjects (P<.01), obesity (P=.02) and occurrence of cardiovascular disease during follow-up (P=.03) increased the longitudinal decline in plasma selenium, whereas gender, education, smoking, alcohol intakes, dyslipidemia, diabetes, hypertension had no effect (P>.05). It may be postulated that obesity and occurrence of cardiovascular events are the main factors associated with plasma selenium fall during ageing. The respective roles played by nutritional and metabolism changes in the mechanism of these associations still need to be explored.
机译：老年人口硒水平下降。心血管疾病是法国老年人的主要死亡原因，硒可以预防心血管疾病。本工作旨在评估9年期间老年人群中心血管相关危险因素与血浆硒变异性之间的关系。 EVA研究（“ Etude du Vieillissement Arteriel”）的711位研究对象（基线时年龄在59至71岁之间）被追踪了9年。每2年重复一次临床检查和生活方式调查表。在基线和研究结束时进行血浆硒测定。使用多元线性回归模型评估了9年血浆硒变异性与基线或随访期间发生的研究危险因素之间的关联。在控制了所有潜在的相关因素之后，受试者的年龄（P <.01），肥胖症（P = .02）和随访期间发生的心血管疾病（P = .03）增加了血浆硒的纵向下降，而性别，教育，吸烟，饮酒，血脂异常，糖尿病，高血压没有影响（P> 0.05）。可以推测，肥胖和心血管事件的发生是与衰老过程中血浆硒下降有关的主要因素。营养和代谢变化在这些关联机制中所起的各自作用仍需探索。

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