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首页> 外文期刊>The Journal of Nutritional Biochemistry >Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells
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Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells

机译：甘草的乙醇/乙醇提取物及其活性化合物异Angustone A诱导DU145人前列腺和4T1鼠乳腺癌细胞中的G1周期阻滞

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摘要

Although licorice is known to exert anticarcinogenic effects, it contains large quantities of glycyrrhizin (GL). which causes severe hypertension. We have previously demonstrated that the hexane/ethanol extract of Glycyrrhiza uralensis (HEGU) contains no detectable GL and suppresses doxorubicin-induced apoptosis in H9c2 rat cardiac myoblasts. The principal objective of this study was to determine whether and by what mechanism HEGU and its active component, isoangustone A, inhibit cell-cycle progression in DU145 human prostate and 4T1 mouse breast cancer cells. HEGU and isoangustone A dose-dependently decreased DNA synthesis and induced G1 phase arrest in both DU145 and 4T1 cells. HEGU and isoangustone A reduced the levels of CDK2 and CDK4 as well as cyclin A and cyclin D1 proteins, and also induced a decrease in CDK2 activity. The addition of HEGU to drinking water significantly suppressed the orthotopic growth of 4T1 allografts and the expression of the proliferating nuclear cell antigen, CDK2 and CDK4 proteins in the tumor tissues. These results demonstrate the potential of HEGU containing isoangustone A as an antitumor agent
机译：尽管已知甘草具有抗癌作用，但它含有大量的甘草甜素（GL）。导致严重的高血压。先前我们已经证明，甘草（HEGU）的己烷/乙醇提取物不含可检测的GL，并且抑制了H9c2大鼠心肌成肌细胞中由阿霉素诱导的凋亡。这项研究的主要目的是确定HEGU及其活性成分异angustone A是否抑制DU145人前列腺细胞和4T1小鼠乳腺癌细胞的细胞周期进程，以及通过何种机制抑制。 HEGU和异angustone A剂量依赖性地降低了DU145和4T1细胞的DNA合成并诱导了G1期阻滞。 HEGU和异Angustone A降低了CDK2和CDK4以及细胞周期蛋白A和细胞周期蛋白D1蛋白的水平，还诱导了CDK2活性的降低。在饮用水中添加HEGU可显着抑制同种异体移植的4T1原位生长以及肿瘤组织中增殖性核细胞抗原，CDK2和CDK4蛋白的表达。这些结果证明了含有异Angustone A的HEGU作为抗肿瘤药物的潜力

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