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首页> 外文期刊>The Journal of Nutritional Biochemistry >Postweaning low-calcium diet promotes later-life obesity induced by a high-fat diet.
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Postweaning low-calcium diet promotes later-life obesity induced by a high-fat diet.

机译：断奶后低钙饮食可促进高脂饮食诱发的肥胖症。

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The aim of this study was to investigate the effects of a postweaning low-calcium diet on later obesity and explore the underlying mechanisms. Ninety-six male rats were weaned at 3 weeks of age, fed standard (STD: 0.50% calcium, n=48) and low-calcium (LC: 0.15% calcium, n=48) diets for 3 weeks, and then fed the standard diet for a 3-week washout period successively. Finally, the STD rats were divided into STD control and high-fat diet (HFD) groups, and the LC ones into LC control and LC+HFD (LCHF) groups. The STD and LC rats were fed the standard diet, while the HFD control and LCFD ones were fed a high-fat diet for 6 weeks to induce obesity. During the three feeding periods, adenosine-monophosphate-activated protein kinase (AMPK) and its responsive proteins phospho-acetyl-coA carboxylase, carnitine palmitoyltransferase 1 and uncoupling protein 3 were persistently down-regulated in the LC group (decreased by 18%, 24%, 18% and 20%, respectively) versus the STD group, and these effects were significantly more pronounced in the LCHFD group (decreased by 21%, 30%, 23% and 25%, respectively) than the HFD group by a later high-fat stimuli, causing more fat and body weight in adulthood. However, lipolysis enzymes, serum leptin, insulin and lipids were not significantly affected until the body weight and fat content changed at 15 weeks of age. The results suggest that the low-calcium diet after weaning promotes rat adult-onset obesity induced by high-fat diet, which might be achieved by programming expressions of genes involved in AMPK pathway
机译：这项研究的目的是调查断奶后低钙饮食对以后肥胖的影响并探讨其潜在机制。对96只雄性大鼠在3周龄时断奶，饲喂标准（STD：0.50％钙，n = 48）和低钙（LC：0.15％钙，n = 48）3周，然后饲喂标准饮食，连续3周清除。最后，将STD大鼠分为STD对照组和高脂饮食（HFD）组，将LC分为LC对照组和LC + HFD（LCHF）组。 STD和LC大鼠接受标准饮食，而HFD对照和LCFD大鼠接受高脂饮食6周以诱发肥胖。在这三个喂养期间，LC组的腺苷一磷酸激活蛋白激酶（AMPK）及其响应蛋白磷酸乙酰乙酰辅酶A羧化酶，肉碱棕榈酰转移酶1和解偶联蛋白3持续下调（分别降低18％，24 ％，18％和20％）分别比STD组和LCHFD组明显更显着（分别降低了21％，30％，23％和25％）。高脂刺激，在成年期引起更多的脂肪和体重。然而，直到15周龄时体重和脂肪含量发生变化，脂解酶，血清瘦素，胰岛素和脂质才受到显着影响。结果表明，断奶后低钙饮食会促进高脂饮食诱导的成年肥胖，这可以通过编程参与AMPK途径的基因表达来实现

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