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首页> 外文期刊>The Journal of Nutritional Biochemistry >4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF- kappa B activity.
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4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF- kappa B activity.

机译：4-iO-甲基厚朴酚通过p21介导的NF-κB活性抑制来抑制结肠肿瘤的生长。

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摘要

Biphenolic components in the Magnolia family have shown several pharmacological activities such as antitumor effects. This study investigated the effects of 4-O-methylhonokiol (MH), a constituent of Magnolia officinalis, on human colon cancer cell growth and its action mechanism. 4-O-methylhonokiol (0-30 micro M) decreased constitutive activated nuclear factor (NF)- kappa B DNA binding activity and inhibited growth of human colon (SW620 and HCT116) cancer cells. It also caused G0-G1 phase cell cycle arrest followed by an induction of apoptotic cell death. However, knockdown with small interfering RNA (siRNA) of p21 or transfection with cyclin D1/Cdk4 binding site-mutated p21 abrogated MH-induced cell growth inhibition, inhibition of NF- kappa B activity as well as expression of cyclin D1 and Cdk4. Conversely, inhibition of NF- kappa B with specific inhibitor or siRNA augmented MH-induced apoptotic cell death. 4-O-methylhonokiol inhibited tumor growth, NF- kappa B activity and expression of antiapoptotic proteins; however, it increased the expression of apoptotic proteins as well as p21 in xenograft nude mice bearing SW620 cancer cells. The present study reveals that MH causes p21-mediated human colon cancer cell growth inhibition through suppression of NF- kappa B and indicates that this compound by itself or in combination with other anticancer agents could be useful for the treatment of cancer.
机译：木兰家族中的双酚成分已显示出多种药理活性，例如抗肿瘤作用。本研究调查了厚朴木兰的组成成分4- O -甲基厚朴酚（MH）对人结肠癌细胞的生长及其作用机制的影响。 4-O-甲基-厚朴酚（0-30 micro M）降低了本构活化核因子（NF）-κB DNA结合活性并抑制了人类结肠癌（SW620和HCT116）癌细胞的生长。它还引起G 0 -G 1 期细胞周期停滞，随后诱导凋亡细胞死亡。然而，用p21的小干扰RNA（siRNA）进行敲除或用细胞周期蛋白D1 / Cdk4结合位点突变的p21转染可废除MH诱导的细胞生长抑制，抑制NF-κB活性以及细胞周期蛋白D1和Cdk4的表达。相反，用特异性抑制剂或siRNA抑制NF-κB会增加MH诱导的凋亡细胞死亡。 4- O -甲基厚朴酚抑制肿瘤生长，NF-κB活性和抗凋亡蛋白的表达;然而，它增加了带有SW620癌细胞的异种移植裸鼠的凋亡蛋白和p21的表达。本研究表明，MH通过抑制NF-κB引起p21介导的人类结肠癌细胞生长抑制，并表明该化合物本身或与其他抗癌药联合可用于治疗癌症。

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