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首页> 外文期刊>The Journal of Nutritional Biochemistry >Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis.
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Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis.

机译：番茄汁中番茄红素的脂质生物标志物和代谢对肝脂肪变性大鼠肝脏的影响。

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Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver disorders, covering steatosis to nonalcoholic steatohepatitis (NASH). Dietary factors may modulate its evolution, and antioxidants have been proposed as therapeutic agents. Among them, lycopene has been demonstrated to prevent the development of steatohepatitis and even to inhibit NASH-promoted early hepatocarcinogenesis induced by a high-fat diet in rats. These conclusions have been related to its antioxidant activity; however, NAFLD is more complex than a simple redox imbalance state since it disturbs several metabolic systems in the liver. In consequence, there is a lack of information related to the action of lycopene beyond antioxidant biomarkers. In this work, NAFLD was induced in rats using a hypercholesterolemic and high-fat diet to evaluate the effect of lycopene consumption from tomato juice on liver metabolism. Several classical antioxidant biomarkers related to NAFLD were measured to check the state of this disease after 7 weeks of the controlled diet. Moreover, a metabolomics platform was applied to measure more than 70 metabolites. Results showed clear differences in the classical antioxidant biomarkers as well as in the metabolic pattern, attending not only to the diet but also to the intake of lycopene from tomato juice. Interestingly, tomato juice administration partially reverted the metabolic pattern from a high-fat diet to a normal diet even in metabolites not related to the redox state, which could lead to new targets for therapeutic agents against NAFLD and to achieving a better understanding of the role of lycopene in liver metabolism.
机译：非酒精性脂肪肝疾病（NAFLD）是最常见的肝脏疾病之一，涵盖了非酒精性脂肪性肝炎（NASH）的脂肪变性。饮食因素可能会调节其进化，并且已提出抗氧化剂作为治疗剂。其中，番茄红素已被证明可以预防脂肪性肝炎的发展，甚至可以抑制高脂饮食诱导的NASH促进的早期肝癌的发生。这些结论与其抗氧化活性有关。但是，NAFLD比简单的氧化还原失衡状态更为复杂，因为它会干扰肝脏中的多个代谢系统。结果，除了抗氧化剂生物标记物之外，缺乏与番茄红素的作用有关的信息。在这项工作中，使用高胆固醇和高脂饮食在大鼠中诱导了NAFLD，以评估番茄汁中番茄红素的摄入对肝脏代谢的影响。在控制饮食7周后，测量了几种与NAFLD相关的经典抗氧化剂生物标志物，以检查该疾病的状态。此外，代谢组学平台已应用于测量70多种代谢产物。结果表明，经典的抗氧化剂生物标志物和代谢模式存在明显差异，不仅影响饮食，而且还影响番茄汁中番茄红素的摄入。有趣的是，番茄汁的使用将代谢模式从高脂饮食部分还原为正常饮食，即使在与氧化还原状态无关的代谢产物中也可能导致新的靶向NAFLD的治疗药物靶点并更好地了解其作用。番茄红素在肝脏代谢中的作用。

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