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首页> 外文期刊>The Journal of Nutritional Biochemistry >Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring
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Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring

机译：补充母体牛磺酸可减轻母体果糖引起的代谢和炎症失调，并部分逆转后代的不良代谢程序

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Excessive fructose consumption is associated with insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD), and high fructose intake during pregnancy can lead to compromised fetal development in the rat Evidence suggests that the amino acid taurine can ameliorate fructose-induced IR and NAFLD in nonpregnant animals. This study investigated the efficacy of taurine supplementation on maternal fructose-induced metabolic dysfunction and neonatal health. Time-mated Wistar rats were randomized to four groups during pregnancy and lactation: (a) control diet (CON), (b) CON supplemented with 1.5% taurine in drinking water (CT), (c) CON supplemented with fructose solution (F) and (d) F supplemented with taurine (FT). Maternal and neonatal weights, plasma cytokines and hepatic gene expression were analyzed. Maternal hyperinsulinemia, increased homeostasis model assessment of IR indices and elevated proinflammatory cytokines were observed in F group and normalized in FT group. Maternal fructose-induced hepatic steatosis accompanied with increased liver weight was ameliorated with taurine supplementation. Maternal hepatic sterol regulatory element-binding protein-1c and fatty acid synthase expression was significantly increased in the F group compared to the CON, CT and FT groups. Neonatal hepatic phosphoenolpyruvate carboxykinase expression was increased in male F neonates compared to the CON, Cl' and FT groups and was increased in female F and FT neonates compared to CON and CT. Interleukin-1 beta expression was decreased in male Cl' and FT neonates compared to other male groups. Hepatic tumour necrosis factor receptor-1 was lower in the male FT group than the F group. These results demonstrate that maternal taurine supplementation can partially reverse fructoseinduced maternal metabolic dysfunction and may ameliorate adverse developmental programming effects in offspring in a sex-specific manner. (C) 2015 Elsevier Inc. All rights reserved.
机译：果糖摄入过多与胰岛素抵抗（IR）和非酒精性脂肪肝疾病（NAFLD）有关，怀孕期间摄入高果糖可导致大鼠胎儿发育受损。证据表明，氨基酸牛磺酸可改善果糖诱导的IR和NAFLD在非怀孕的动物中。这项研究调查了牛磺酸补充剂对孕妇果糖诱导的代谢功能障碍和新生儿健康的功效。定期配对的Wistar大鼠在怀孕和哺乳期间随机分为四组：（a）对照饮食（CON），（b）补充有1.5％牛磺酸的饮用水（CT），（c）CON补充有果糖溶液（F ）和（d）辅以牛磺酸（FT）的F。分析了孕妇和新生儿的体重，血浆细胞因子和肝基因表达。 F组观察到产妇高胰岛素血症，IR指数稳态模型评估增加和促炎细胞因子升高，而FT组则恢复正常。补充牛磺酸可改善孕妇果糖引起的肝脂肪变性并伴有肝脏重量增加。与CON，CT和FT组相比，F组的孕妇肝固醇调节元件结合蛋白1c和脂肪酸合酶表达显着增加。与CON，C1'和FT组相比，男性F新生儿的新生儿肝脏磷酸烯醇丙酮酸羧激酶表达增加，而与CON和CT相比，在F和FT雌性新生儿中则增加。与其他男性组相比，男性C1和FT新生儿的白细胞介素1β表达降低。男性FT组的肝肿瘤坏死因子受体1低于F组。这些结果表明，补充母体牛磺酸可以部分逆转果糖引起的母体代谢功能障碍，并可以通过性别特异性的方式改善后代对发育的不良编程影响。 （C）2015 Elsevier Inc.保留所有权利。

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