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首页> 外文期刊>The Journal of Nutritional Biochemistry >Effects of short-term walnut consumption on human microvascular function and its relationship to plasma epoxide content
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Effects of short-term walnut consumption on human microvascular function and its relationship to plasma epoxide content

机译：短期食用核桃对人体微血管功能的影响及其与血浆环氧含量的关系

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Improved vascular function after the incorporation of walnuts into controlled or high-fat diets has been reported; however, the mechanism(s) underlying this effect of walnuts is(are) poorly defined. The objective of the current study was to evaluate the acute and short-term effects of walnut intake on changes in microvascular function and the relationship of these effects to plasma epoxides, the cytochrome-P450-derived metabolites of fatty acids. Thirty-eight hypercholesterolemic postmenopausal women were randomized to 4 weeks of 5 g or 40 g of daily walnut intake. All outcomes were measured after an overnight fast and 4 h after walnut intake. Microvascular function, assessed as the reactive hyperemia index (RHI), was the primary outcome measure, with serum lipids and plasma epoxides as secondary measures. Compared to 5 g of daily walnut intake, consuming 40 g/d of walnuts for 4 weeks increased the RHI and Framingham RHI. Total cholesterol and low- and high-density cholesterol did not significantly change after walnut intake. The change in RHI after 4 weeks of walnut intake was associated with the change in the sum of plasma epoxides (r=0.65, P=.002) but not with the change in the sum of plasma hydroxyeicosatetraenoic acids. Of the individual plasma epoxides, arachidonic-acid-derived 14(15)-epoxyeicosatrienoic acid was most strongly associated with the change in microvascular function (r=0.72, P.001). These data support the concept that the intake of walnut-derived fatty acids can favorably affect plasma epoxide production, resulting in improved microvascular function. (C) 2015 Elsevier Inc. All rights reserved.
机译：据报道，在将核桃加入控制饮食或高脂饮食后，血管功能得到改善;但是，对核桃这种作用的机理尚不明确。本研究的目的是评估核桃摄入对微血管功能变化的急性和短期影响，以及这些影响与血浆环氧化物，细胞色素P450衍生的脂肪酸代谢产物之间的关系。 38名绝经后的高胆固醇血症妇女随机分为4周，每天摄入5克或40克核桃。在过夜禁食后和核桃摄入后4小时测量所有结果。评估为反应性充血指数（RHI）的微血管功能是主要的结局指标，而血脂和血浆环氧化物则是次要指标。与每天摄入5克核桃相比，每天摄入40克核桃持续4周的RHI和Framingham RHI有所提高。摄入核桃后，总胆固醇和低，高密度胆固醇没有明显变化。核桃摄入4周后RHI的变化与血浆环氧化物总量的变化有关（r = 0.65，P = .002），但与血浆羟基二十碳四烯酸总量的变化无关。在各个血浆环氧化物中，花生四烯酸衍生的14（15）-环氧二十碳三烯酸与微血管功能的变化最密切相关（r = 0.72，P <.001）。这些数据支持以下概念：摄入核桃衍生的脂肪酸可以有利地影响血浆环氧化合物的产生，从而改善微血管功能。 （C）2015 Elsevier Inc.保留所有权利。

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