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首页> 外文期刊>The Journal of Nutritional Biochemistry >Oral exposure to the anti-pyridoxine compound 1-amino D-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B-6 deficient rats
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Oral exposure to the anti-pyridoxine compound 1-amino D-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B-6 deficient rats

机译：口服暴露于抗吡rats醇化合物1-氨基D-脯氨酸可进一步通过中硫缺乏维生素B-6的大鼠通过转硫途径干扰同型半胱氨酸代谢

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摘要

Pyridoxal 5'-phosphate (PLP; a B-6 vitamer) serves as an important cofactor in a myriad of metabolic reactions, including the transsulfuration (TS) pathway, which converts homocysteine (Hcy) to cysteine. While overt vitamin B-6 deficiency is rare, moderate deficiency is common and may be exacerbated by anti-pyridoxine factors in the food supply. To this end, we developed a model of moderate B-6 deficiency and a study was conducted to examine the in vivo effect of 1-amino D-proline (1ADP), an anti-pyridoxine factor found in flaxseed, on indices of Hcy metabolism through the TS pathway in moderately B-6 deficient rats. Male weaning rats received a semi-purified diet containing either 7 mg/kg (control; CD) or 0.7 mg/kg (moderately deficient; MD) diet of pyridoxine- hydrochloride (PN center dot HCl), each with 1 of 4 levels of 1ADP, viz. 0, 0.1, 1 and 10 mg/kg diet for 5 weeks. Perturbations in vitamin B-6 biomarkers were more pronounced in the MD group. Plasma PLP was significantly reduced, while plasma Hcy (8-fold) and cystathionine (11-fold) were increased in rats consuming the highest amount of 1ADP in the MD group. The activities of hepatic cystathionine beta-synthase and cystathionine gamma-lyase enzymes were significantly reduced in rats consuming the highest 1ADP compared to the lowest, for both levels of PN-HCl. Dilation of hepatic central veins and sinusoids, mild steatosis and increased liver triglycerides were present in MD rats consuming the highest 1ADP level. The current data provide evidence that the consumption of an anti-pyridoxine factor linked to flaxseed may pose a risk for subjects who are moderate/severe vitamin B-6 deficient. (C) 2015 Elsevier Inc. All rights reserved.
机译：吡rid醛5'-磷酸酯（PLP; B-6维他命）在许多代谢反应（包括将高半胱氨酸（Hcy）转化为半胱氨酸的转硫（TS）途径）中充当重要的辅因子。虽然很少出现明显的维生素B-6缺乏症，但中度缺乏症很常见，在食品供应中可能会因抗吡rid醇因素而加剧。为此，我们开发了中度B-6缺乏症模型，并进行了一项研究，以研究亚麻中发现的一种抗吡py醇因子1-氨基D-脯氨酸（1ADP）对Hcy代谢的体内作用通过中度B-6缺陷大鼠的TS途径。雄性断奶大鼠接受半精制饮食，其中含吡ido醇盐酸盐（PN中心点HCl）饮食为7 mg / kg（对照; CD）或0.7 mg / kg（中度缺乏; MD）饮食，每一种均含4种水平的1ADP，即0、0.1、1和10 mg / kg的饮食持续5周。 MD组中维生素B-6生物标志物的扰动更为明显。在MD组中，摄入最高1ADP的大鼠血浆PLP显着降低，而血浆Hcy（8倍）和胱硫醚（11倍）升高。对于两种水平的PN-HCl，在消耗最高1ADP的大鼠中，肝脏胱硫醚β-合酶和胱硫醚γ-裂合酶的活性均显着降低。消耗最高1ADP水平的MD大鼠存在肝中央静脉和正弦波扩张，轻度脂肪变性和肝甘油三酯增加。当前数据提供证据表明，食用与亚麻籽有关的抗吡rid醇因子可能会对中度/重度维生素B-6缺乏症的受试者构成风险。 （C）2015 Elsevier Inc.保留所有权利。

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