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首页> 外文期刊>The Journal of Nutritional Biochemistry >Dietary calcium attenuation of body fat gain during high-fat feeding in mice.
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Dietary calcium attenuation of body fat gain during high-fat feeding in mice.

机译：高脂喂养小鼠饮食中钙对人体脂肪增加的衰减作用。

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Human epidemiological studies have supported the hypothesis that a dairy food-rich diet is associated with lower fat accumulation, although prospective studies and intervention trials are not so conclusive and contradictory data exist in animal models. The purpose of this study was to assess the effects on body weight and fat depots of dairy calcium (12 g/kg diet) in wild-type mice under ad libitum high-fat (43%) and normal-fat (12%) diets and to gain comprehension on the underlying mechanism of dairy calcium effects. Our results show that calcium intake decreases body weight and body fat depot gain under high-fat diet and accelerates weight loss under normal-fat diet, without differences in food intake. No differences in gene or protein expression of UCP1 in brown adipose tissue or UCP2 in white adipose tissue were found that could be related with calcium feeding, suggesting that calcium intake contributed to modulate body weight in wild-type mice by a mechanism that is not associated with activation of brown adipose tissue thermogenesis. UCP3 protein but not gene expression increased in muscle due to calcium feeding. In white adipose tissue there were effects of calcium intake decreasing the expression of proteins related to calcium signalling, in particular of stanniocalcin 2. CaSR levels could play a role in decreasing cytosolic calcium in adipocytes and, therefore, contribute to the diminution of fat accretion. Results support the anti-obesity effect of dietary calcium in male mice and indicate that, at least at the time-point studied, activation of thermogenesis is not involved. All rights reserved, Elsevier.
机译：人类流行病学研究支持以下假设：富含乳制品的饮食与较低的脂肪蓄积有关，尽管前瞻性研究和干预试验并非如此结论性的，并且动物模型中存在矛盾的数据。这项研究的目的是评估随意摄入高脂（43％）和正常脂肪（12％）饮食对野生型小鼠中乳钙（12 g / kg饮食）的体重和脂肪堆积的影响。并了解乳制品钙作用的潜在机制。我们的结果表明，在高脂饮食下钙的摄入减少了体重，增加了人体的脂肪储备，而在正常脂肪饮食下钙的摄入加速了减肥，而食物摄入没有差异。没有发现棕色脂肪组织中UCP1或白色脂肪组织中UCP2的基因或蛋白质表达存在差异，这可能与钙的摄入有关，这表明钙的摄入通过一种不相关的机制来调节野生型小鼠的体重激活棕色脂肪组织的生热作用。由于补钙，肌肉中的UCP3蛋白增加，但基因表达没有增加。在白色脂肪组织中，钙的摄入会降低与钙信号相关的蛋白质（特别是锡钙素2）的表达。CaSR的水平可能在减少脂肪细胞中的胞质钙中起一定作用，因此，有助于减少脂肪的积聚。结果支持膳食钙对雄性小鼠的抗肥胖作用，并表明至少在所研究的时间点，不涉及生热的激活。保留所有权利，Elsevier。

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