• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Nutritional Biochemistry >Cancer stem cells: potential target for bioactive food components.
【24h】

Cancer stem cells: potential target for bioactive food components.

机译：癌症干细胞：生物活性食品成分的潜在靶标。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cancer stem cells often have phenotypic and functional characteristics similar to normal stem cells including the properties of self-renewal and differentiation. Recent findings suggest that uncontrolled self-renewal may explain cancer relapses and may represent a critical target for cancer prevention. It is conceivable that the loss of regulatory molecules resulting from inappropriate consumption of specific foods and their constituents may foster the aberrant self-renewal of cancer stem cells. In fact, increasing evidence points to the network delivering signals for self-renewal from extracellular compartments to the nucleus including changes in stem cell environments, inducible expression of microRNAs, hyperplastic nuclear chromatin structures, and the on/off of differentiation process as possible sites of action for bioactive food components. Diverse dietary constituents such as vitamins A and D, genistein, (--)-epigallocatechin-3-gallate (EGCG), sulforaphane, curcumin, piperine, theanine and choline have been shown to modify self-renewal properties of cancer stem cells. The ability of these bioactive food components to influence the balance between proliferative and quiescent cells by regulating critical feedback molecules in the network including dickkopf 1 (DKK-1), secreted frizzled-related protein 2 (sFRP2), B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) and cyclin-dependent kinase 6 (CDK6) may account for their biological response. Overall, the response to food components does not appear to be tissue or organ specific, suggesting there may be common cellular mechanisms. Unquestionably, additional studies are needed to clarify the physiological role of these dietary components in preventing the resistance of tumor cells to traditional drugs and cancer recurrence
机译：癌症干细胞通常具有类似于正常干细胞的表型和功能特征，包括自我更新和分化的特性。最近的发现表明不受控制的自我更新可能解释了癌症的复发，并且可能代表了预防癌症的关键目标。可以想象，由于不当食用特定食物及其成分而导致的调节分子的丢失可能会促进癌症干细胞异常的自我更新。实际上，越来越多的证据表明，该网络将信号从细胞外区室自我更新到细胞核，包括干细胞环境的变化，microRNA的诱导表达，增生核染色质结构以及分化过程的开/关（可能是该位点）。生物活性食品成分的作用。多种饮食成分如维生素A和D，金雀异黄素，（-）-表没食子儿茶素-3-没食子酸酯（EGCG），萝卜硫烷，姜黄素，胡椒碱，茶氨酸和胆碱已被证明可改变癌症干细胞的自我更新特性。这些生物活性食品成分通过调节网络中的关键反馈分子（包括dickkopf 1（DKK-1），分泌的卷曲相关蛋白2（sFRP2），B细胞特异性莫洛尼鼠白血病）影响增殖细胞与静止细胞之间平衡的能力。病毒整合位点1（Bmi-1）和细胞周期蛋白依赖性激酶6（CDK6）可能解释了它们的生物学反应。总体而言，对食物成分的反应似乎不是组织或器官特异的，表明可能存在共同的细胞机制。毫无疑问，需要进一步的研究来阐明这些饮食成分在预防肿瘤细胞对传统药物和癌症复发的抗性中的生理作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号