Involvement of de novo ceramide synthesis in pro-inflammatory adipokine secretion and adipocyte-macrophage interaction

Hamada Yoji; Nagasaki Hiroshi; Fujiya Atsushi; Seino Yusuke; Shang Qing-Long; Suzuki Takeshi; Hashimoto Hiroyuki; Oiso Yutaka

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Involvement of de novo ceramide synthesis in pro-inflammatory adipokine secretion and adipocyte-macrophage interaction

机译：从头神经酰胺合成参与促炎性脂肪因子分泌和脂肪细胞-巨噬细胞相互作用

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Interaction between adipocytes and macrophages has been suggested to play a central role in the pathogenesis of obesity. Ceramide, a sphingolipid de novo synthesized from palmitate, is known to stimulate pro-inflammatory cytokine secretion from multiple types of cells. To clarify whether de novo synthesized ceramide contributes to cytokine dysregulation in adipocytes and macrophages, we observed cytokine secretion in mature 3T3-L1 adipocytes (L1) and RAW264.7 macrophages (RAW) cultured alone or co-cultured under the suppression of de novo ceramide synthesis.

机译：已经表明，脂肪细胞和巨噬细胞之间的相互作用在肥胖症的发病机理中起着核心作用。神经酰胺，一种从棕榈酸酯合成的鞘氨醇，已知能刺激多种细胞分泌促炎性细胞因子。为了阐明从头合成的神经酰胺是否会导致脂肪细胞和巨噬细胞中的细胞因子失调，我们观察了成熟的3T3-L1脂肪细胞（L1）和RAW264.7巨噬细胞（RAW）单独培养或在新生神经酰胺抑制下共培养的细胞因子分泌。合成。

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来源
《The Journal of Nutritional Biochemistry》 |2014年第12期|共8页
作者
Hamada Yoji; Nagasaki Hiroshi; Fujiya Atsushi; Seino Yusuke; Shang Qing-Long; Suzuki Takeshi; Hashimoto Hiroyuki; Oiso Yutaka;
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正文语种 eng
中图分类生物化学;
关键词
Ceramide; Palmitate; Adipocytes; Macrophages; Cytokines; Serine-palmitoyl transferase;

机译：神经酰胺;棕榈酸酯;脂肪细胞;巨噬细胞;细胞因子;丝氨酸-棕榈酰转移酶;

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专利

1. Involvement of de novo ceramide synthesis in pro-inflammatory adipokine secretion and adipocyte-macrophage interaction [J] . Hamada Yoji, Nagasaki Hiroshi, Fujiya Atsushi, The Journal of Nutritional Biochemistry . 2014,第12期

机译：从头神经酰胺合成参与促炎性脂肪因子分泌和脂肪细胞-巨噬细胞相互作用
2. Involvement of de novo ceramide biosynthesis in macrophage death induced by activation of ATP-sensitive P2X7 receptor [J] . Raymond MN, Le Stunff H FEBS letters. . 2006,第1期

机译：从头神经酰胺的生物合成参与激活ATP敏感的P2X7受体诱导的巨噬细胞死亡
3. Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells. [J] . Gopalan A, Weiping Yu, Qing Jiang, Molecular Nutrition and Food Research . 2012,第12期

机译：从头神经酰胺合成参与人乳腺癌细胞中γ-生育酚和γ-生育三烯酚诱导的细胞凋亡。
4. Computational Modeling of A Metabolic Pathway in Ceramide de novo Synthesis [C] . Dhingra, S., Freedenberg, Engineering in Medicine and Biology Society, 2007 Annual International Conference of the IEEE . 2007

机译：从头合成中代谢途径的计算模型
5. Protein-ligand and protein-protein interactions involved in de novo initiation of RNA synthesis by the hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp). [D] . Kim, Young-Chan. 2006

机译：丙肝病毒（HCV）RNA依赖性RNA聚合酶（RdRp）参与RNA合成从头开始的蛋白质-配体和蛋白质-蛋白质相互作用。
6. Inhibition of Ceramide De Novo Synthesis Affects Adipocytokine Secretion and Improves Systemic and Adipose Tissue Insulin Sensitivity [O] . Agnieszka U. Blachnio-Zabielska, Hady Razak Hady, Adam R. Markowski, 1999

机译：神经酰胺从头合成的抑制影响脂肪细胞因子的分泌，并改善全身和脂肪组织对胰岛素的敏感性。
7. Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance [O] . Xie Linglin Jr 100

机译：了解脂肪因子分泌和脂肪细胞 - 巨噬细胞的细胞相互作用，寻找胰岛素敏感性和耐药性的分子基础

Involvement of de novo ceramide synthesis in pro-inflammatory adipokine secretion and adipocyte-macrophage interaction

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