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首页> 外文期刊>The Journal of Nutritional Biochemistry >Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediators.
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Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediators.

机译：来自果渣橄榄油的长链脂肪醇调节促炎介质的释放。

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摘要

Pomace olive oil is a by-product of olive oil extraction that is traditionally produced and consumed in Spain. The nonglyceride matter of this oil is a good source of interesting minor compounds, like long-chain fatty alcohols, which are present free or as part of waxes. In the present study, long-chain fatty alcohols were isolated from the nonglyceride fraction of pomace olive oil, and the composition was identified and quantified. The major components of long-chain fatty alcohols were tetracosanol, hexacosanol and octacosanol. We investigated the ability of long-chain fatty alcohols from pomace olive oil to inhibit the release of different proinflammatory mediators in vitro by cells involved in inflammatory processes. Long-chain fatty alcohols significantly and dose-dependently decreased nitric oxide production by RAW 264.7 murine macrophages stimulated with lipopolysaccharide. Western blot analysis showed that nitric oxide reduction was a consequence of the inhibition of inducible nitric oxide synthetase expression. Long-chain fatty alcohols also reduced tumor necrosis factor- alpha and prostaglandin E2 production, although the potency of inhibition for the latter was lower. On the other hand, long-chain fatty alcohols significantly reduced thromboxane A2 production in rat peritoneal neutrophils stimulated with the calcium ionophore A-23187. The reduction of eicosanoid release was related to the inhibition of phospholipase A2 enzyme activity by long-chain fatty alcohols, reaching an inhibitory concentration 50% value of 6.2 mug/ml. These results showed that long-chain fatty alcohols may have a protective effect on some mediators involved in the inflammatory damage development, suggesting its potential value as a putative functional component of pomace olive oil. All rights reserved, Elsevier.
机译：渣油橄榄油是橄榄油提取的副产品，传统上在西班牙生产和消费。这种油的非甘油酯物质是有趣的次要化合物（例如长链脂肪醇）的良好来源，这些化合物不存在或作为蜡的一部分存在。在本研究中，从果渣橄榄油的非甘油酯级分中分离出长链脂肪醇，并对成分进行了鉴定和定量。长链脂肪醇的主要成分是十四烷醇，十六烷醇和十八烷醇。我们研究了来自果渣橄榄油的长链脂肪醇在体外抑制参与炎症过程的细胞释放不同促炎介质的能力。长链脂肪醇显着且剂量依赖性地降低了用脂多糖刺激的RAW 264.7鼠巨噬细胞产生的一氧化氮。蛋白质印迹分析表明，一氧化氮还原是抑制诱导型一氧化氮合成酶表达的结果。长链脂肪醇还减少了肿瘤坏死因子-α和前列腺素E2的产生，尽管对后者的抑制作用较低。另一方面，长链脂肪醇显着减少了钙离子载体A-23187刺激的大鼠腹膜中性粒细胞中血栓烷A2的产生。类花生酸释放的减少与长链脂肪醇对磷脂酶A2酶活性的抑制有关，其抑制浓度50％值为6.2杯/毫升。这些结果表明，长链脂肪醇可能对参与炎症损害发展的某些介质具有保护作用，表明其潜在的价值可能是果渣橄榄油的功能成分。保留所有权利，Elsevier。

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