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首页> 外文期刊>The Journal of Nutritional Biochemistry >Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides.
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Age- and brain region-specific effects of dietary vitamin K on myelin sulfatides.

机译：饮食中维生素K对髓磷脂硫化物的年龄和大脑区域特异性影响。

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Dysregulation of myelin sulfatides is a risk factor for cognitive decline with age. Vitamin K is present in high concentrations in the brain and has been implicated in the regulation of sulfatide metabolism. Our objective was to investigate the age-related interrelation between dietary vitamin K and sulfatides in myelin fractions isolated from the brain regions of Fischer 344 male rats fed one of two dietary forms of vitamin K: phylloquinone or its hydrogenated form, 2',3'-dihydrophylloquinone (dK), for 28 days. Both dietary forms of vitamin K were converted to menaquinone-4 (MK-4) in the brain. The efficiency of dietary dK conversion to MK-4 compared to dietary phylloquinone was lower in the striatum and cortex, and was similar to that in the hippocampus. There were significant positive correlations between sulfatides and MK-4 in the hippocampus (phylloquinone-supplemented diet, 12 and 24 months; dK-supplemented diet, 12 months) and cortex (phylloquinone-supplemented diet, 12 and 24 months). No significant correlations were observed in the striatum. Furthermore, sulfatides in the hippocampus were significantly positively correlated with MK-4 in serum. This is the first attempt to establish and characterize a novel animal model that exploits the inability of dietary dK to convert to brain MK-4 to study the dietary effects of vitamin K on brain sulfatide in brain regions controlling motor and cognitive functions. Our findings suggest that this animal model may be useful for investigation of the effect of the dietary vitamin K on sulfatide metabolism, myelin structure and behavior functions.
机译：髓磷脂硫酸盐的失调是随着年龄而认知下降的危险因素。维生素K以高浓度存在于大脑中，并且与硫酸脂代谢的调节有关。我们的目的是研究从饲喂两种饮食形式维生素K的菲舍尔344雄性大鼠大脑区域分离的髓鞘级分中的饮食维生素K和硫化物之间的年龄相关关系：叶醌或氢化形式2'，3' -二氢叶醌（dK），持续28天。两种饮食形式的维生素K在大脑中都转化为甲萘醌4（MK-4）。与饮食中的叶绿醌相比，饮食中dK转化为MK-4的效率在纹状体和皮质中较低，与海马中的相似。海马中的硫化物和MK-4之间有显着正相关（补充叶绿醌的饮食，分别为12和24个月;补充dK的饮食，分别为12个月和12个月和24个月）。在纹状体中未观察到明显的相关性。此外，海马中的硫化物与血清中的MK-4显着正相关。这是首次尝试建立和表征新颖的动物模型，该模型利用饮食中的dK无法转化为大脑MK-4来研究维生素K对控制运动和认知功能的大脑区域中脑硫素的饮食作用。我们的发现表明，这种动物模型可能有助于研究饮食中维生素K对硫苷脂代谢，髓磷脂结构和行为功能的影响。

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