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首页> 外文期刊>The Journal of Nutritional Biochemistry >Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis.
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Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis.

机译：反式10，顺式12结合的亚油酸改变了多形肥胖小鼠肝脂肪变性小鼠肝脏基因的表达。

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摘要

The trans-10, cis-12 isomer of conjugated linoleic acid (CLA) causes a rapid reduction of body and adipose mass in mice. In addition to changes in adipose tissue, numerous studies have reported alterations in hepatic lipid metabolism. Livers of CLA-fed mice gain mass, partly due to lipid accumulation; however, the precise molecular mechanisms are unknown. To elucidate these mechanisms, we examined fatty acid composition and gene expression profiles of livers from a polygenic obese line of mice fed 1% trans-10, cis-12-CLA for 14 days. Analysis of gene expression data led to the identification of 1393 genes differentially expressed in the liver of CLA-fed male mice at a nominal P value of .01, and 775 were considered significant using a false discovery rate (FDR) threshold of .05. While surprisingly few genes in lipid metabolism were impacted, pathway analysis found that protein kinase A (PKA) and cyclic adenosine monophosphate (cAMP) pathways signaling pathways were affected by CLA treatment and 98 of the 775 genes were found to be regulated by hepatocyte nuclear factor 4 alpha, a transcription factor important in controlling liver metabolic status.
机译：共轭亚油酸（CLA）的反式10，顺式12异构体可导致小鼠体内和脂肪量迅速减少。除了脂肪组织的变化，许多研究还报告了肝脂质代谢的变化。用CLA喂养的小鼠的肝脏会增重，部分是由于脂质的积聚。但是，确切的分子机制尚不清楚。为了阐明这些机制，我们检查了喂食1％反式10，顺式12-CLA 14天的多基因肥胖系小鼠肝脏的脂肪酸组成和基因表达谱。基因表达数据分析导致鉴定了在CLA喂养的雄性小鼠肝脏中以P值为0.01的差异表达的1393个基因，使用0.05的错误发现率（FDR）阈值认为775个基因具有重要意义。尽管出乎意料的是，脂质代谢中的几个基因受到影响，但通路分析发现蛋白激酶A（PKA）和单磷酸环腺苷（cAMP）通路的信号通路受到CLA处理的影响，发现775个基因中有98个受肝细胞核因子调节4 alpha，对控制肝代谢状态重要的转录因子。

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