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首页> 外文期刊>Biomolecular engineering >Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone.
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Fabrication of a three-dimensional nanostructured biomaterial for tissue engineering of bone.

机译：用于骨骼组织工程的三维纳米结构生物材料的制造。

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A plasma process for the surface modification of HA powders has been developed. Acrylic acid and acrylic acid/octadiene plasma deposited films onto HA particles have demonstrated to interact with SBF allowing the calcium dissolution-precipitation mechanism. Therefore, a nanostructured composite between HA and a self-assembling peptide scaffold (RAD16-I) has been developed. The differentiation of mESC in this scaffold has been studied, in order to test the osteogenic capacity of the new composite material. We have observed that the mESC can be induced to produce Ca salts (mineralization) in a 3D-microenvironment and moreover, this activity can be enhanced by the presence of HA particles into the nanofiber scaffold.
机译：已经开发了用于HA粉末的表面改性的等离子体工艺。已证明在HA颗粒上的丙烯酸和丙烯酸/辛二烯等离子体沉积膜与SBF相互作用，从而允许钙溶解-沉淀机制。因此，已经开发了HA与自组装肽支架（RAD16-I）之间的纳米结构复合物。为了测试新型复合材料的成骨能力，已经研究了该支架中mESC的分化。我们已经观察到，可以在3D微环境中诱导mESC产生Ca盐（矿化），此外，可以通过在纳米纤维支架中存在HA颗粒来增强此活性。

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