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首页> 外文期刊>Biomolecular engineering >Silica sol-gel matrix doped with Photolon molecules for sensing and medical therapy purposes.
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Silica sol-gel matrix doped with Photolon molecules for sensing and medical therapy purposes.

机译：掺杂有光子分子的二氧化硅溶胶-凝胶基质，用于传感和医学治疗。

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Photolon is one of the new photosensitisers that has found application in photodynamic therapy (PDT). Its chemical structure has a partially reduced porphyrin moiety and its molecular structure is comparable to chlorin e(6), which can be isolated after hydrolysis of the 5-membered exocyclic beta-ketoester moiety of pheophorbide a. For this study, a Photolon doped sol-gel matrix was produced in the form of coatings deposited on silica fibers cores. The material was produced from sols prepared from the silicate precursor TEOS mixed with ethyl alcohol. The sol-gel films were prepared with factor R=20, where R denotes the solvent-to-precursor molar ratio. Hydrochloric acid was added as a catalyst in the correct proportion to ensure acid hydrolysis (pH approximately 2). The mixture was stirred at room temperature for 4h using a magnetic stirrer (speed 400rpm). The coated fibers were examined in different environments, liquid and gaseous, at different pH values and with various zinc cation concentrations. The chemical reactions were studied by means of spectroscopic methods, whereby the fluorescence response was studied. It was demonstrated that Photolon immobilized in a sol-gel matrix is accessible for the environment and shows visible response to the external changes. Furthermore, it was observed that these reactions are reversible. These biomaterials are also examined as carriers for PDT. It was also proved that a toxic effect is observed an environment with microorganisms, meaning that doped coatings have photodynamic activity.
机译：Photolon是已在光动力疗法（PDT）中得到应用的新型光敏剂之一。它的化学结构具有部分还原的卟啉部分，其分子结构与二氢卟酚e（6）相当，后者可以将脱镁叶绿酸a的5元环外β-酮酸酯部分水解后分离出来。对于本研究，以沉积在二氧化硅纤维芯上的涂层形式生产了光子掺杂的溶胶-凝胶基质。该材料是由硅酸盐前体TEOS与乙醇混合制成的溶胶制成的。制备的溶胶-凝胶膜的系数为R = 20，其中R表示溶剂与前体的摩尔比。以正确的比例添加盐酸作为催化剂，以确保酸水解（pH约为2）。使用磁力搅拌器（速度400rpm）在室温下将混合物搅拌4h。在不同的液体和气体环境中，在不同的pH值和不同的锌阳离子浓度下，检查涂覆的纤维。通过光谱方法研究化学反应，从而研究荧光响应。已证明固定在溶胶-凝胶基质中的光子对于环境是可接近的，并且显示出对外部变化的可见响应。此外，观察到这些反应是可逆的。还检查了这些生物材料作为PDT的载体。还证明了在微生物环境中观察到毒性作用，这意味着掺杂的涂层具有光动力活性。

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